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Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates
Mechanical forces play a major role in the regulation of cell adhesion and cytoskeletal organization. In order to explore the molecular mechanism underlying this regulation, we have investigated theExpand
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Hierarchical assembly of cell-matrix adhesion complexes.
The adhesion of cells to the extracellular matrix is a dynamic process, mediated by a series of cell-surface and matrix-associated molecules that interact with each other in a spatially andExpand
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Interactions between acidic proteins and crystals: stereochemical requirements in biomineralization.
  • L. Addadi, S. Weiner
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 June 1985
Acidic matrix macromolecules are intimately involved in biological crystal growth. In vitro experiments, in which crystals of calcium dicarboxylate salts were grown in the presence of asparticExpand
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Mollusc larval shell formation: amorphous calcium carbonate is a precursor phase for aragonite.
The larval shells of the marine bivalves Mercenaria mercenaria and Crassostrea gigas are investigated by polarized light microscopy, infrared spectroscopy, Raman imaging spectroscopy, and scanningExpand
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Taking Advantage of Disorder: Amorphous Calcium Carbonate and Its Roles in Biomineralization
Amorphous calcium carbonate (ACC) in its pure form is highly unstable, yet some organisms produce stable ACC, and cases are known in which ACC functions as a transient precursor of more stableExpand
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Amorphous calcium carbonate transforms into calcite during sea urchin larval spicule growth
Sea urchin larvae form an endoskeleton composed of a pair of spicules. For more than a century it has been stated that each spicule comprises a single crystal of the CaCO3 mineral, calcite. We showExpand
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Design strategies in mineralized biological materials
Organisms have been producing mineralized skeletons for the past 550 million years. They have evolved many different strategies for improving these materials at almost all hierarchical levelsExpand
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Structure of the nacreous organic matrix of a bivalve mollusk shell examined in the hydrated state using cryo-TEM.
During mollusk shell formation, the mineral phase forms within an organic matrix composed of beta-chitin, silk-like proteins, and acidic glycoproteins rich in aspartic acid. The matrix is widelyExpand
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