L. Addadi

Publications345
h-index82
Citations29,396
Highly Influential Citations745
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Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates
TLDR
The results put clear constraints on the possible molecular mechanisms for the mechanosensory response of focal adhesions to applied force.
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Hierarchical assembly of cell-matrix adhesion complexes.
TLDR
It is shown that the formation of matrix adhesions is a hierarchical process, consisting of several sequential molecular events, which depends on actomyosin contractility and matrix pliability.
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Mollusc larval shell formation: amorphous calcium carbonate is a precursor phase for aragonite.
TLDR
It is concluded that ACC fulfills an important function in mollusc larval shell formation and it is conceivable that ACC may also be involved in adult shell formation.
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Taking Advantage of Disorder: Amorphous Calcium Carbonate and Its Roles in Biomineralization
Amorphous calcium carbonate (ACC) in its pure form is highly unstable, yet some organisms produce stable ACC, and cases are known in which ACC functions as a transient precursor of more stable…
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Interactions between acidic proteins and crystals: stereochemical requirements in biomineralization.
  • L. Addadi, S. Weiner
  • Chemistry
    Proceedings of the National Academy of Sciences…
  • 1 June 1985
TLDR
In vitro experiments, in which crystals of calcium dicarboxylate salts were grown in the presence of aspartic acid-rich proteins, revealed a stereochemical property common to all the interacting faces that is important in biomineralization.
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Mollusk shell formation: a source of new concepts for understanding biomineralization processes.
The biological approach to forming crystals is proving to be most surprising. Mollusks build their shells by using a hydrophobic silk gel, very acidic aspartic acid rich proteins, and apparently also…
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Amorphous calcium carbonate transforms into calcite during sea urchin larval spicule growth
TLDR
It is shown that an additional mineral phase, amorphous calcium carbonate, is present in the sea urchin larval spicule, and that this inherently unstable mineral transforms into calcite with time.
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Mollusk Shell Formation: A Source of New Concepts for Understanding Biomineralization Processes
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Design strategies in mineralized biological materials
Organisms have been producing mineralized skeletons for the past 550 million years. They have evolved many different strategies for improving these materials at almost all hierarchical levels…
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Control of Aragonite or Calcite Polymorphism by Mollusk Shell Macromolecules
Many mineralizing organisms selectively form either calcite or aragonite, two polymorphs of calcium carbonate with very similar crystalline structures. Understanding how these organisms achieve this…
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