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Restoration of auditory evoked responses by human ES cell-derived otic progenitors
TLDR
A protocol to induce differentiation from human embryonic stem cells (hESCs) using signals involved in the initial specification of the otic placode results in two types of otic progenitors able to differentiate in vitro into hair-cell-like cells and auditory neurons that display expected electrophysiological properties. Expand
Functional interactions of genes mediating convergent extension, knypek and trilobite, during the partitioning of the eye primordium in zebrafish.
TLDR
The authors' results correlate the cyclopia phenotype with the abnormal location of hh-expressing cells with respect to the optic primordium and hypothesize that at this distance, midline cells are not in an appropriate position to physically separate the eye field and that HH and other signals do not reach the appropriate target cells. Expand
Functional and developmental expression of a zebrafish Kir1.1 (ROMK) potassium channel homologue Kcnj1
TLDR
It is shown that a potassium‐selective channel that underlies salt reabsorption and potassium excretion in the human kidney is also expressed in zebrafish in cells that are important regulators of salt balance. Expand
Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene
TLDR
It is proposed that Gpr126 acts through a cAMP-mediated pathway to control the outgrowth and adhesion of canal projections in the zebrafish ear via the regulation of extracellular matrix gene expression. Expand
Nkcc1 (Slc12a2) is required for the regulation of endolymph volume in the otic vesicle and swim bladder volume in the zebrafish larva
TLDR
Zebrafish little ears (lte) mutant shows a collapse of the otic vesicle in the larva, apparently owing to a loss of endolymphatic fluid in the ear, together with an over-inflation of the swim bladder, validating zebrafish as a model for the study ofendolymph disorders. Expand
A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle
TLDR
It is shown that the three sox genes belonging to group E provide a link between otic induction pathways and subsequent otic patterning: they act redundantly to maintain sox10 expression throughout otic tissue and to restrict fgf8 expression to anterior macula regions. Expand
Loss of Function but No Gain of Function Caused by Amino Acid Substitutions in the Hexapeptide of Hoxa1 In Vivo
TLDR
It is shown that mice with mutations in the Hoxa1 hexapeptide display hindbrain, cranial nerve, and skeletal defects highly reminiscent of those reported for the H Coxa1 loss of function. Expand
The zebrafish inner ear
TLDR
In the zebrafish otic vesicle, the atoh genes have an early proneural function in establishing the prosensory domain, and are also required later for hair cell differentiation. Expand
Aminoglycoside ototoxicity and hair cell ablation in the adult gerbil: A simple model to study hair cell loss and regeneration
TLDR
There is little or no neuronal loss following the ototoxic insult, even at 8 months post-damage, similar to the situation often seen in the human, where functioning neurons can persist even decades after hair cell loss, contrasting with the rapid, secondary degeneration found in rats, mice and other small mammals. Expand
Comparison of the effects of HGF, BDNF, CT-1, CNTF, and the branchial arches on the growth of embryonic cranial motor neurons.
TLDR
The results show that HGF acts as a generalized rather than a specific neurotrophic factor and guidance cue for cranial motor neurons, and the branchial arches also had general growth-promoting effects on all motor neuron subpopulations, but at different axial levels differentially. Expand
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