L. A. Simeoni

Publications56
h-index15
Citations1,119
Highly Influential Citations37
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Genus Pouteria: chemistry and biological activity
The genus Pouteria belongs to the family Sapotaceae and can be widely found around the World. These plants have been used as building material, as food, because the eatable fruits, as well as… Expand
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α-Amylase inhibitors: a review of raw material and isolated compounds from plant source.
Inhibition of α-amylase, enzyme that plays a role in digestion of starch and glycogen, is considered a strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity, as… Expand
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Thyroid Hormone Response Element Organization Dictates the Composition of Active Receptor*
Thyroid hormone (triiodothyronine, T3) is known to activate transcription by binding heterodimers of thyroid hormone receptors (TRs) and retinoid X receptors (RXRs). RXR-TRs bind to T3 response… Expand
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Inhibitory activity of α-amylase and α-glucosidase by plant extracts from the Brazilian cerrado.
Diabetes mellitus is the most common disease in the world. One therapeutic approach for treating diabetes is inhibition of α-amylase and α-glucosidase activities to reduce postprandial blood glucose… Expand
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Evidence for Multidrug Resistance-1 P-Glycoprotein-dependent Regulation of Cellular ATP Permeability
Abstract. The mechanisms responsible for regulating epithelial ATP permeability and purinergic signaling are not well defined. Based on the observations that members of the ATP-binding cassette… Expand
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GQ-16, a Novel Peroxisome Proliferator-activated Receptor γ (PPARγ) Ligand, Promotes Insulin Sensitization without Weight Gain
Background: PPARγ agonists improve insulin sensitivity but also evoke weight gain. Results: GQ-16 is a PPARγ partial agonist that blocks receptor phosphorylation by Cdk5 and improves insulin… Expand
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Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms
BackgroundThyroid receptors, TRα and TRβ, are involved in important physiological functions such as metabolism, cholesterol level and heart activities. Whereas metabolism increase and cholesterol… Expand
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Analysis of P‐glycoprotein–mediated membrane transport in human peripheral blood lymphocytes using the UIC2 shift assay
During transport‐associated adenosine triphosphate hydrolysis, P‐glycoprotein (Pgp) undergoes conformation transitions detected by UIC2, a functional anti‐Pgp monoclonal antibody. A newly developed… Expand
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Thyroid hormone export varies among primary cells and appears to differ from hormone uptake.
We characterized T3 efflux in primary cultures of cells derived from human placenta, neonatal rat cardiac myocytes, and rat inner medullary collecting ducts (IMCD). The T3 efflux rate was highest in… Expand
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Thyroid Hormone Export in Rat FRTL-5 Thyroid Cells and Mouse NIH-3T3 Cells Is Carrier-Mediated, Verapamil-Sensitive, and Stereospecific1.
Export of l-T3 out of the cell is one factor governing the cellular T3 content and response. We previously observed in liver-derived cells that T3 export was inhibited by verapamil, suggesting that… Expand
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