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[Experimental study of histamine-liberating properties of eremomycin].
TLDR
Preliminary administration of dimedrol decreased intensity of the pad edema induced by the antibiotics, which was at the average 2 times less pronounced than after the use of eremomycin and kanamycin.
[Eremomycin in the treatment of antibiotic-associated colitis in golden hamsters].
TLDR
When the animals were infected with a pathogenetic strain of Clostridium difficile followed by exposure to lincomycin the use of eremomycin produced the similar effect: some animals survived, the others died in later periods.
[Preclinical toxicological study of the new antibiotic eremomycin. Its acute toxicity for laboratory animals].
TLDR
Unlike the other representatives of glycopeptide antibiotics, eremomycin had practically no local irritating effect which provided its recommendation for clinical trials not only as an intravenous but also intramuscular antibiotic.
[Experimental study on chemotherapeutic efficacy, acute toxic action and nephrotoxicity of combinations of eremomycin with tobramycin].
TLDR
The experiments showed that the chemotherapeutic effect of eremomycin in combination with tobramycin was of synergistic nature and had a dose-depended nephrotoxicity.
[Experimental study of antibacterial activity, therapeutic effectiveness and toxic properties of the combination of tobramycin and carbenicillin].
TLDR
Tobramycin combination with carbenicillin was studied experimentally and it was shown that the combination had mainly synergistic action on clinical strains of Pseudomonas aeruginosa which was confirmed in treatment of experimental sepsis caused by the organism.
[Effect of doxorubicin on animals in multiple intravenous administration].
TLDR
Histological examination of the organs and tissues of the animals killed at different periods after multiple intravenous administration of doxorubicin in various doses showed that doxorbicin had mainly the damaging effect on the gastrointestinal epithelium, heart muscle, epithelia of the proximal tubuli of the kidneys, lymphoid organs and testis.
[Characteristics of the functional state of the placental mitochondria in interrupted pregnancy].
TLDR
Findings indicated that spontaneous miscarriage was preceded by inhibition of oxidative phosphorylation and it was suggested that functional impairment of placenta can be corrected by administration of preparations containing thiol group (cysteine).
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