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Metabolism of the analgesic drug ULTRAM ® (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites
The in vitro metabolism of tramadol was conducted using a human liver microsomal fraction in the presence of an NADPH-generating system and appeared to be major routes, forming seven O -desmethyl/ N -des methyl and hydroxycyclohexyl metabolites. Expand
Metabolism of the analgesic drug, tramadol hydrochloride, in rat and dog
The in vitro metabolism of tramadol was conducted using rat hepatic S9 fraction in the presence of an NADPH-generating system and eight metabolites, consisting of 16 Phase I metabolites and eight conjugates (seven glucuronides, one sulphate), were isolated and tentatively identified. Expand
Oral Administration of Cyclopentane Neuraminidase Inhibitors Protects Ferrets against Influenza Virus Infection
The nasal inflammatory cellular response, fever, and nasal signs were reduced while ferret activity was not, with activity remaining similar to uninfected animals, and BCX-1812 seemed to be the most efficacious at lower doses. Expand
The in vitro metabolism of thalicarpine, an aporphine-benzyltetrahydroisoquinoline alkaloid, in the rat. API-MS/MS identification of thalicarpine and metabolites.
  • W. Wu, L. A. Mckown
  • Chemistry, Medicine
  • Journal of pharmaceutical and biomedical analysis
  • 1 August 2002
The proposed metabolic pathways for thalicarpine are proposed, and the three metabolic pathways are: (1) N-demethylation; (2) aporphine ring oxidation; and (3) benzylic oxidation/reduction. Expand
Recent advances in biotransformation of CNS and cardiovascular agents.
In this article, excretion and metabolism of compounds are reviewed from the CNS agents to the cardiovascular agents, including structures of parent compounds, their metabolites, metabolic pathways, and methods for the isolation, profiling, quantification and structural identification of unchanged compounds and metabolites. Expand
Disposition of bepridil in laboratory animals and man.
Comparison of the proposed pathways revealed qualitative similarity among species and linear but non-proportional, dose-related increases in the area under the curve (AUC) for plasma Bp vs. time were noted after increasing oral doses of Bp. Expand
The Novel, Orally Active, Delta Opioid RWJ-394674 Is Biotransformed to the Potent Mu Opioid RWJ-413216
RWJ-394674 is a delta opioid receptor agonist that appears to augment its antinociceptive effect through biotransformation to a novel mu opioid receptor-selective agonist. Expand
Metabolism and excretion of the antiepileptic/antimigraine drug, topiramate in animals and humans
The most dominant metabolite of TPM in mice, male rats, rabbits and dogs appeared to be formed by the hydrolysis of the 2,3-{ie151-3}-isopropylidene group. Expand
Biotransformation of the antipsychotic agent, mazapertine, in dog--mass spectral characterization and identification of metabolites.
Biotransformation of the antipsychotic agent, mazapertine, was studied after a single oral administration of 14C-mazapERTine succinate to six beagle dogs to identify major metabolites and seven metabolic pathways for the formation of metabolites were identified. Expand