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A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.
- L. A. Gossett, D. Kelvin, E. Sternberg, E. Olson
- Chemistry, Medicine
- Molecular and cellular biology
- 1 November 1989
Evidence is provided for a novel myocyte-specific enhancer-binding factor, MEF-2, that is expressed early in the differentiation program and is suppressed by specific polypeptide growth factors during myogenesis. Expand
Dexamethasone-dependent inhibition of differentiation of C2 myoblasts bearing steroid-inducible N-ras oncogenes
Oncogenic ras proteins reversibly activate an intracellular cascade that prevents establishment of the differentiated phenotype and the inability of ras to extinguish muscle- specific gene expression in terminally differentiated myotubes suggests that ras may interfere with an early step in the pathway of myoblasts toward the differentiated state. Expand
Transfectomas expressing both secreted and membrane-bound forms of chimeric IgE with anti-viral specificity.
The potential utility of the transfectoma cells and the chimeric IgE in studying the roles of membrane-bound IgE and effects of anti-IgE antibodies on IgE-producing B cells is demonstrated. Expand
A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes
Exposure of skeletal myoblasts to growth factor-deficient medium results in transcriptional activation of muscle-specific genes, including the muscle creatine kinase gene (mck). Tissue specificity,… Expand
Ontogeny of maternal and newly transcribed mRNA analyzed by in situ hybridization during development of Caenorhabditis elegans.
The results suggest that the major transcriptional effort for poly(A)+ RNA begins at the 90- to 125-cell stage of C. elegans embryogenesis and that the poly( a)+ RNA present in the cytoplasm prior to this time is primarily of maternal origin. Expand
A squash technique demonstrating embryonic nuclear cleavage of the nematode Caenorhabditis elegans.
A simple squash technique was developed which permits the observation of individual nuclei during embryogenesis of Caenorhabditis elegans and yields superimposable growth curves upon correction for temperature. Expand
Can anti-IgE be used to treat allergy?
Because IgE does not appear to be essential and because CGP 51901 has been rigorously tested to confirm its non-anaphylactic nature, this treatment is not expected to have any adverse effects and to be safe and to have a good probability of being effective when it is tested in human clinical trials. Expand
An Epitope on Membrane-Bound But Not Secreted IgE: Implications in Isotype-Specific Regulation
Here it is proposed that the extracellular portions of the membrane-anchoring segments of the heavy chains of mIgs, referred to as “mIg isotype-specific” or “ migis” peptides, may provide the antigenic sites for the isotypes-specific targeting of B cells in vivo. Expand
Muscle differentiation in normal and cleavage-arrested mutant embryos of Caenorhabditis elegans
The results suggest that the biosynthesis of muscle-specific proteins by nematode embryonic muscle cells is regulated by mechanisms intrinsic to these cells. Expand