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An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota
Analysis of the faecal microbiota in IBS and control subjects identified several clear associations with clinical data and a distinct subset of IBS patients with alterations in their microbiota that did not correspond to IBS subtypes, as defined by the Rome II criteria. Expand
Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions
Functional and anatomical evidence for abnormal neuroimmune interactions has been found in patients with IBS and the link between immune alterations and severity of gastrointestinal symptoms and the positive effect of anti-inflammatory treatments in IBS further highlight the relevance of neuro immune interactions in this condition. Expand
Deviations in human gut microbiota: a novel diagnostic test for determining dysbiosis in patients with IBS or IBD
Dysbiosis is associated with many diseases, including irritable bowel syndrome (IBS), inflammatory bowel diseases (IBD), obesity and diabetes. Potential clinical impact of imbalance in the intestinalExpand
Clinical trial: the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome – a randomized, double‐blind, controlled study
This study highlights the need to understand more fully the mechanism behind the immune response to probiotic bacteria in order to assess the importance of these bacteria in relieving constipation. Expand
Identification of an Intestinal Microbiota Signature Associated With Severity of Irritable Bowel Syndrome.
IBS symptom severity is found to be associated negatively with microbial richness, exhaled CH4, presence of methanogens, and enterotypes enriched with Clostridiales or Prevotella species. Expand
Crosstalk at the mucosal border: importance of the gut microenvironment in IBS
The crosstalk between the gut microbiota, the enteroendocrine system, the immune system and the role of intestinal permeability in patients with IBS is highlighted. Expand
The intra-individual variability of faecal calprotectin: a prospective study in patients with active ulcerative colitis.
Since the levels of calprotectin increased with longer time between the bowel movements, it seems most appropriate to analyse stool from the first bowel movement in the morning, and storage of stool samples at room temperature for more than 3 days is not advisable. Expand
Gut Microbiota as Potential Orchestrators of Irritable Bowel Syndrome
Potential links between the gut microbiota and IBS are highlighted by discussing the current knowledge of the gut bacteria and bacterial-host interactions and how alterations to these interactions could exacerbate, induce or even help alleviate IBS. Expand
T-Cell Activation in Patients With Irritable Bowel Syndrome
IBS patients have an increased frequency of activated T cells, demonstrated by the expression of activation markers and reduced proliferation in response to restimulation in vitro, consistent with the hypothesis of low-grade immune activation in IBS. Expand
IBS-like Symptoms in Patients with Ulcerative Colitis in Deep Remission Are Associated with Increased Levels of Serum Cytokines and Poor Psychological Well-being
Poor psychological well-being and increased serum cytokine levels, but not colonic low-grade inflammation, were associated with IBS-like symptoms. Expand