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During protein synthesis, the ribosome controls the movement of tRNA and mRNA by means of large-scale structural rearrangements. We describe structures of the intact bacterial ribosome from Escherichia coli that reveal how the ribosome binds tRNA in two functionally distinct states, determined to a resolution of ~3.2 angstroms by means of x-ray(More)
In bacteria, the translocation of tRNA and mRNA with respect to the ribosome is catalyzed by the conserved GTPase elongation factor-G (EF-G). To probe the rate-determining features in this process, we imaged EF-G-catalyzed translocation from two unique structural perspectives using single-molecule fluorescence resonance energy transfer. The data reveal that(More)
of two influenza A viruses from a pilot whale. et al. Mass mortality of harbor seals: pneumonia associated with influenza A virus. Pathogen exposure and blood chemistry in the Washington, USA population of northern sea otters (Enhydra lutris kenyoni). pathogen exposure and general health status of live and beach-cast Washington sea otters (Enhydra lutris(More)
Virtual machine (VM) technology enables multiple VMs to share resources on the same host. Resources allocated to the VMs should be re-configured dynamically in response to the change of application demands or resource supply. Because VM execution involves privileged domain and VM monitor, this causes uncertainties in VMs' resource to performance mapping and(More)
In Ohio, United States, in early 2014, a deltacoronavirus was detected in feces and intestine samples from pigs with diarrheal disease. The complete genome sequence and phylogenetic analysis of the virus confirmed that the virus is closely related to a porcine deltacoronavirus (porcine coronavirus HKU15) reported in Hong Kong in 2012.
To the Editor: Porcine corona-virus (PorCoV) HKU15 is a single-stranded, positive-sense, enveloped RNA virus belonging to the genus Deltacoronavirus (family Coronaviri-dae). PorCoV HKU15 was first identified in 2012 in a surveillance study from China (1). Until February 2014, however, the role of this virus strain in clinical diseases of pigs had not been(More)
Accurate estimation of the state of charge (SOC) of batteries is one of the key problems in a battery management system. This paper proposes an adaptive SOC estimation method based on unscented Kalman filter algorithms for lithium (Li)-ion batteries. First, an enhanced battery model is proposed to include the impacts due to different discharge rates and(More)
Noise artifacts are one of the key obstacles in applying continuous monitoring and conrputer-assisted analysis of lung sounds. Traditional adaptive noise cancellation (ANC) methodologies work reasonably well when signal and noise are stationary and independent. Clinical lung sound auscultation encounters an acoustic environment in which breath sounds are(More)
Norovirus (NoV) P domain complexes, the 24 mer P particles and the P dimers, induced effective humoral immunity, but their role in the cellular immune responses remained unclear. We reported here a study on cellular immune responses of the two P domain complexes in comparison with the virus-like particle (VLP) of a GII.4 NoV (VA387) in mice. The P domain(More)
Influenza-like illnesses (ILI), a subset of acute respiratory infections (ARI), are a significant source of morbidity and mortality worldwide. ILI can be caused by numerous pathogens, however; there is limited information on the etiology and epidemiology of ILI in China. We performed a one-year surveillance study (2010) of viral etiology causing ILI and(More)