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The clonal expansion theory of the immune system was first proposed over 30 years age (Jerne, 1955; Burnet, 1959). It still forms the basis of current thinking about the immune system. It was not obvious to the authors of this paper that the combinatorial possibilities of the 20 available amino acids in antigen peptides could result in a system that could(More)
OBJECTIVES The aetiology of non-gonococcal urethritis (NGU) in a considerable proportion of men remains unaccounted for. We wished to investigate the possible aetiological role of bacterial vaginosis (BV), the commonest cause of abnormal discharge in women, in this condition. METHODS We carried out two studies. In the first, case-control, study, we(More)
We examined the influence of demographic, social and economic background of people with HIV/AIDS in London on total community and hospital services costs. This was a retrospective study of community and hospital service use, needs and costs based on structured questionnaires administered by trained interviewers and costing information obtained from the(More)
STUDY OBJECTIVES To describe mathematically the relationship between patterns of sexual mixing in the general population and those of people with gonorrhoea infection, and hence to estimate the sexual mixing matrix for the general population. DESIGN Integration of data describing sexual behaviour in the general population, with data describing sexual(More)
OBJECTIVES To explore the relation between receipt of sex education and experience of first intercourse. SUBJECTS AND DESIGN The national survey of sexual attitudes and lifestyles is based on a sample of 18,876 respondents aged 16-59, randomly selected from the Post Office's small-user postcode address file. Data were collected between May 1990 and(More)
OBJECTIVES To study the presentation and survival of patients who present with their first diagnosis of being HIV positive at the same time as their AIDS defining illness. DESIGN Retrospective study of patients presenting with AIDS between 1991 and 1993. SETTING Department of genitourinary medicine, St Mary's Hospital, London. MAIN OUTCOME MEASURES(More)
BACKGROUND Previous studies suggest that concurrent sexually transmitted infection may enhance HIV transmission. This paper explores some theoretical consequences of this using a mathematical model of transmission of HIV and other STD pathogens. OBJECTIVES To develop a deterministic mathematical model to describe the heterosexual transmission dynamics of(More)