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OBJECTIVES To explore the relation between receipt of sex education and experience of first intercourse. SUBJECTS AND DESIGN The national survey of sexual attitudes and lifestyles is based on a sample of 18,876 respondents aged 16-59, randomly selected from the Post Office's small-user postcode address file. Data were collected between May 1990 and(More)
The clonal expansion theory of the immune system was first proposed over 30 years age (Jerne, 1955; Burnet, 1959). It still forms the basis of current thinking about the immune system. It was not obvious to the authors of this paper that the combinatorial possibilities of the 20 available amino acids in antigen peptides could result in a system that could(More)
OBJECTIVES The aetiology of non-gonococcal urethritis (NGU) in a considerable proportion of men remains unaccounted for. We wished to investigate the possible aetiological role of bacterial vaginosis (BV), the commonest cause of abnormal discharge in women, in this condition. METHODS We carried out two studies. In the first, case-control, study, we(More)
OBJECTIVE To describe the use of hospital-based services and associated costs over time for HIV-infected individuals by disease stage and year of treatment. METHODS Data on service use were abstracted from inpatient and outpatient case-notes of 459 HIV-infected patients (121 asymptomatic and 338 AIDS patients) treated at St Mary's Hospital, London between(More)
There has been considerable interest recently in using the occurrence of gonorrhoea infection as an indicator of sexual behaviour relevant to the transmission of human immunodeficiency virus. Mathematical models of gonorrhoea transmission can predict increasing incidence with decreasing sexual activity in the population, due to a resultant concentration of(More)
We examined the influence of demographic, social and economic background of people with HIV/AIDS in London on total community and hospital services costs. This was a retrospective study of community and hospital service use, needs and costs based on structured questionnaires administered by trained interviewers and costing information obtained from the(More)
STUDY OBJECTIVES To describe mathematically the relationship between patterns of sexual mixing in the general population and those of people with gonorrhoea infection, and hence to estimate the sexual mixing matrix for the general population. DESIGN Integration of data describing sexual behaviour in the general population, with data describing sexual(More)