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This review focuses on the action of intracellular magnesium ion on the inositol 1,4,5-trisphosphate (IP3) receptor, the almost ubiquitous membrane-bound Ca2+ channel gated by the intracellular second messenger IP3. Experimental data have shown that Mg2+ is a non-competitive inhibitor of the IP3-gated Ca2+ channel and of [3H]-IP3 binding. The relevance of(More)
A random sample of 2,854 subjects aged 35-64 was examined in the town of Vicenza (Italy) as part of the 'Hypertension Management Audit Project'. Pearson's correlation coefficient and multivariate analysis considering systolic and diastolic blood pressure, age and body mass index (BMI) were performed. SBP was more closely correlated with age than DBP. BMI(More)
The authors report their experience in the determination of the infarct size (IS) by means of enzymatic analysis in a series of 281 consecutive patients (230 males, 51 females) admitted to the CCU because of myocardial infarction (MI), who did not benefit from thrombolytic therapy in the acute phase. To obtain the enzymatic IS, the serum activity of(More)
BACKGROUND Many factors influence diastolic function indexes obtained by monitoring left ventricular filling. Recent reports suggest that the study of myocardial wall velocity with Doppler tissue imaging (DTI) can give diastolic function parameters that are less affected by the same factors. An altered diastolic function has been demonstrated with invasive(More)
Doppler tissue imaging (DTI) is an adaptation of the color-doppler, which allows the measurement of low-speed myocardial wall movement. We describe the case of a 51-year-old woman suffering from cardiac amyloidosis with serious endangerment of the diastolic function and mitral flow velocity pattern that was indistinguishable from the normal. The(More)
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