L. V. Maslova

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The experiments on white rats have shown that the induction of 4 hour stress produces an acute increase in beta-endorphin level, as well as characteristic changes in ACTH, cortisol, insulin, thyroxin and triiodothyronine concentrations. Different types of adaptation (training with short stress periods or injection of rhodiola rosea extract) promote a(More)
The course of administration of Rhodiola rosea extract was studied for effects on the pattern of stress-induced cardiac damage which was assessed by 99mTc-pyrophosphate accumulation in the heart. Rhodiola rosea was found to prevent stress-induced cardiac damage. Simultaneously, myocardial catecholamines and cAMP levels were measured. Rhodiola rosea was(More)
A course injection of Rhodiola rosea extract for eight days was reported to increase the resistance of experimental animals to adrenalin- or CaCl2-induced arrhythmias. Preliminary injection of naloxone in a dose of 0.5 mg/kg eliminated the antiarrhythmic effect of Rhodiola. Indomethacin had no effect the antiarrhythmic action of Rhodiola. The antiarrhythmic(More)
In experiments on white Wistar rats the effect of acute 4-hour freezing at -10 degrees C on contractile function of the hearts isolated by the Langendorff technique, and the protective efficacy of Rhodiola rosea extract were investigated. The obtained results testify to the fact that acute cooling leads to a decrease in myocardial contractile activity that(More)
After adaptation of rats to extreme conditions treatment of the animals with dalargin (Leu-enkephalin derivative resistant to enzymatic hydrolysis) caused a decrease of catabolism rate in myocardium under stress conditions. Involvement of endogenous opioid peptides in formation of "structure track" during body adaptation to extreme conditions is discussed.
It was shown in experiments on albino rats that their adaptation by a series of "trainings" or a course of treatment with Rhodida rosea extract produced a marked cardioprotective effect during emotional-pain stress. Adaptation of rats to stress factors induced simultaneously regular changes of the cyclic nucleotide content in the myocardium, thus(More)
An adaptive defensive stress reaction may turn into an "adaptive disease", as Selye noted, ff the response of the organism is excessive or the duration of stress is prohibitively long [7]. The impact of low temperatures on the homoiothermic organism is considered a pathological manifestation of the stress reaction and must be corrected. The different(More)
The decreased ventricular fibrillation threshold (VFT) in the first 5 days of restriction results from stress-induced changes in myocardial autonomic innervation, as shown by elevated cardiac content of cAMP and lowered levels of cGMP, and a rise in the plasma concentrations of corticosterone and deoxycorticosterone. Ultimately, these changes enhance(More)