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Stoichiometrically, exact candidate pathways or mechanisms for deriving the rate law of a catalytic or complex reaction can be determined through the synthesis of networks of plausible elementary reactions constituting such pathways. A rigorous algorithmic method is proposed for executing this synthesis, which is exceedingly convoluted due to its(More)
The current work demonstrates that separation-network synthesis (SNS) problems can be transformed into process-network synthesis (PNS) problems: The SNS problems constitute a particular class of PNS problems. Thus, the transformed SNS problems are solvable by resorting to the P-graph methodology originally introduced for the PNS problems. The methodology(More)
Among separation systems, the ones comprising separators effected by different separation methods have been steadily gaining attention lately. Our earlier work has revealed that it is exceedingly complicated to optimally synthesize via superstructure any of these separation networks featuring simple and sharp separators, multiple feed and product streams,(More)
Graph Theoretic Process Network Synthesis is described as an introduction to biological networks. Genetic, protein and metabolic systems are considered. The theoretical work of Kauffman is discussed and amplified by critical property excursions. The scaling apparent in biological systems is shown. Applications to evolution and reverse engineering are(More)
Adenanthin, a natural diterpenoid isolated from the leaves of Isodon adenanthus, has recently been reported to induce leukemic cell differentiation by targeting peroxiredoxins (Prx) I and II. On the other hand, increasing lines of evidence propose that these Prx proteins would become potential targets to screen drugs for the prevention and treatment of(More)
" The reigning question in biology is not the survival of the fittest but the arrival of the fittest. " 1 Abstract Qualitative attributes of the region between order and disorder are examined to explore models of genetic and protein networks. Results show how the connectivity of vertices and the strength of their connections are related and how their(More)