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Staphylococcus aureus is a gram-positive bacterium frequently isolated from patients with bloodstream infections. Endothelial cells (EC) play an important role in host defence against bacteria, and recent reports have shown that infection of EC with S. aureus induces expression of cytokines and cell surface receptors involved in activating the innate immune(More)
The effects of 19 opiate agonists and antagonists on kindled amygdaloid seizures in the rat were studied. The mu agonists tended to reduce the length of elicited afterdischarges and behavioral ranks, while markedly increasing postictal electroencephalogram spikes and behavioral arrest time. These effects were reversed by naloxone. The kappa agonists reduced(More)
An in vitro paired-pulse orthodromic stimulation technique was used to examine the effects of propofol on excitatory afferent terminals, CA1 pyramidal cells and recurrent collateral evoked inhibition in the rat hippocampal slice. Hippocampal slices 400 microns thick were perfused with oxygenated artificial cerebrospinal fluid, and electrodes were placed in(More)
Neonatal male rats were exposed to lindane or corn oil directly by gavage or indirectly by maternal exposure. All surviving offspring were implanted with amygdaloid electrodes 90 days after weaning. Amygdaloid kindling began 10 days later using standard procedures. Neonatal lindane-exposed rats kindled significantly faster (9.9 +/- 0.5 days) than control(More)
Rats receiving daily oral administrations of lindane were kindled using daily amygdaloid stimulation. In naive rats lindane exposure increased the probability of evoking an afterdischarge and increased the probability that a convulsive response would be associated with the afterdischarge. During kindling lindane increased the rate of acquisition of the(More)
The effects of an aversive stimulus were assessed on subsequent conditioned behavior in rats. Operant conditioning began two weeks after the prior aversive stimulus (10 shocks, 1.0 mA, 5 seconds) was administered. The schedule was continuous reinforcement for food with a secondary light reinforcement. Once stable response rates had been achieved, a shock of(More)
Rats were kindled during exposure to caffeine (50 mg/kg) or saline given IP twenty minutes before daily electrical stimulation of the amygdala until 3 kindled amygdaloid seizures (KAS) occurred. They were then stimulated for 3 days without drug pretreatment followed by 5 additional days with drug pretreatment. There were no significant differences between(More)