L Sh Shteĭnberg

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The neurovirulence of L-16 vaccine measles virus strains and its 9 clonal variants was investigated in intracerebrally infected Macaca mulatta monkeys. Two groups of clones were distinguished: one comprised variants that caused destructive changes of neurons in the brain and diffuse proliferative gliosis, and the second variants that caused changes of a(More)
Measles virus strains Edmonston and L-16 have been studied in 10 intracerebrally (i.c.) infected monkeys and in 155 guinea pigs infected into the anterior eye chamber. The strains appeared to differ in pathogenicity for monkeys and guinea pigs. The more pathogenic Edmonston strain caused encephalitis in monkeys, whereas in guinea pigs it caused(More)
The time of persistence of measles antigen was studied in Macaca mulatta and green monkeys inoculated intracerebrally with the vaccine L-16 strain of measles virus and its two genetically homologous variants. Two clones differing in their neurovirulence were used. The results of the study showed correlation between the time of the antigen persistence in the(More)
Magnesium sulphate in concentrations of 25-50 mM induced reproducible increase in titers of extracellular measles virus (by 0.5-2.0 1g TCD50/0.5 ml) in Japanese quail embryo cells. MgSO4 effect was observed with all methods of cell cultivation: stationary, roller, or on microcarriers. Its effect was associated not with its stabilizing influence on the(More)
Residual neurovirulence of measles virus vaccine strains "Leningrad-16", "Moscow-5" and of cloned variant of L-16 strain--clone 3, differing in the degree of attenuation, was studied in intracerebrally (i.c.) infected Cercopithecus aethiops monkeys, receiving cortisone and/or antilymphocyte serum (ALS). Whereas the sensitivity for detection of the potential(More)
Six different methods were used for examinations for the presence of antibodies to mumps virus in 43 sera of donors varying in ages from 18 to 58 years. Judging by the percentage of positive results, most sensitive tests included: radial hemolysis (95.3), neutralization (88.4-81.4), immunofluorescence (83.7). Comparison of the results obtained in these(More)
The L-16 vaccine strain of measles virus produced in L-41 cell cultures of various size (0.5-0.2 mm in diameter), with clear or opaque centers, thus being genetically heterogeneous by the S and P markes. The clones derived from the L-16 strain differed from it and from each other in a number of genetic properties. Clones isolated at different temperatures,(More)
The pathological process typical of measles and mumps infections was reproduced clinically and morphologically in 250 experimental guinea pigs infected into the anterior eye chamber with different strains of measles and mumps viruses. The intraocular inoculation of measles virus induced in guinea pigs the signs of iridocyclitis and follicular(More)
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