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After the Women's Health Initiative found that the risks of hormone therapy outweighed the benefits, a need for alternative drugs to treat menopausal symptoms has emerged. We explored the possibility that botanical agents used in Traditional Chinese Medicine for menopausal symptoms contain ERbeta-selective estrogens. We previously reported that an extract(More)
Estrogens produce biological effects by interacting with two estrogen receptors, ERalpha and ERbeta. Drugs that selectively target ERalpha or ERbeta might be safer for conditions that have been traditionally treated with non-selective estrogens. Several synthetic and natural ERbeta-selective compounds have been identified. One class of ERbeta-selective(More)
BACKGROUND Bone marrow-derived mesenchymal stem cells (BMSCs) are a widely researched adult stem cell population capable of differentiation into various lineages. Because many promising applications of tissue engineering require cell expansion following harvest and involve the treatment of diseases and conditions found in an aging population, the effect of(More)
PURPOSE There is a need for objective measures of pediatric intrinsic hand muscle strength as the current standard, the manual muscle test, lacks sensitivity to clinically important changes in muscle strength. We report the development, reliability, and normative values of the Peg Restrained Intrinsic Muscle Evaluator (PRIME), a device that quantifies(More)
Available air temperature models do not adequately account for the influence of terrain on nocturnal air temperatures. An empirical model for night time air temperatures was developed using a network of one hundred and forty inexpensive temperature sensors deployed across the Bitterroot National Forest, Montana. A principle component analysis (PCA) on(More)
R esearch in consumer psychology shows that customers seek reasons for service failures and that attributions of blame moderate the effects of failure on the level of customer satisfaction. This paper extends research on service operations failures by hypothesizing that attributions of blame also affect what matters to the customer during service failures.(More)
Bezielle is a botanical extract that has selective anti-tumor activity, and has shown a promising efficacy in the early phases of clinical testing. Bezielle inhibits mitochondrial respiration and induces reactive oxygen species (ROS) in mitochondria of tumor cells but not in non-transformed cells. The generation of high ROS in tumor cells leads to heavy DNA(More)
Long-term estrogen deficiency increases the risk of obesity, diabetes and metabolic syndrome in postmenopausal women. Menopausal hormone therapy containing estrogens might prevent these conditions, but its prolonged use increases the risk of breast cancer, as wells as endometrial cancer if used without progestins. Animal studies indicate that beneficial(More)
Many barrel or columnar cacti, including some in the Atacama Desert, produce their reproductive tissue at or near the terminal apices of solitary or minimally branched stems that lean toward the equator, reportedly to maximize exposure to photosynthetically active radiation (PAR). Those with lateral reproductive tissue, often produce the tissue on the(More)
Acknowledgement. Abstract. We apply Exploratory Data Analysis to some of the basic models of neoclassical computational finance. These include the portfolio selection algorithm of Markowitz, the Capital Market Line of Sharpe, and the option pricing model of Black– Scholes–Merton. We demonstrate that the Markowitzian assumption of positive correlation of(More)
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