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In acute experiments on cats changes in the background sympathetic activity in the renal nerve, chosen as a model of vaso-constrictor nerve, together with arterial pressure shifts have been found following injections of nitric oxide (NO) containing drugs into the ventrolateral medulla. This is the first report of evidence that both sodium nitroprusside,(More)
In acute experiments on anesthetized (urethane) normotensive rats, we studied the hemodynamic effects of unilateral microinjections of a nitric oxide (NO) donor, sodium nitroprusside, into the medullary nuclei participating in central cardiovascular control. We studied also the effects of modulation of the intensity of NO production: enhancing its synthesis(More)
In acute experiments on normotensive rats and those with genetically determined hypertension (urethane anesthesia), we studied hemodynamic effects resulting from modulation of the activities of neuronal NO synthase (NOS-1), arginase II, and superoxide dismutase, and also of the mitochondrial permeability in medullary cardiovascular neurons. Unilateral(More)
In acute experiments on cats, the effects of injections of nitric oxide (NO) donors and an inhibitor of its synthesis into the sympathoexcitatory neuronal structures in the ventrolateral medulla (VLM) were studied to examine their effects on the peripheral mechanisms of the cardiovascular control. Unilateral injections of NO donors, nitroglycerine (1.3–5.2(More)
These studies were designed to provide information on both GABA influences on the neuronal structures within the rostral ventrolateral medulla (RVLM) involved in the cardiovascular control, and fine structure of the GABA-sensitive RVLM in cats. By electron microscopy, the S-type asymmetric junctions (believed to mediate excitation) as well as F-type(More)
In acute experiments on anesthetized rats, we studied the effects of modulation of the mitochondrial permeability in medullary cardiovascular neurons (nucl. tractus solitarii, NTS, nucl. ambiguus, AMB, paramedian reticular nucleus, PMn, and lateral reticular nucleus, LRN) on the systemic arterial pressure (SAP). We were the first to show that the(More)
Administration of endothelin induced a hypertensive response in anesthetised cats. The mechanism of this response seems to involve an augmentation of the resistance of peripheral vessels due to enhanced descending sympatho-activating influences.
Physical inactivity can be considered one of the major risk factors related to cardiovascular diseases. There are reasons to believe that the positive effect of exercise training is, to a large extent, mediated by modulation of the nervous control of the circulation system. In our previous studies, we showed that modulation of mitochondrial permeability(More)
Data showing the uneven distribution of serotonin in brain-stem nuclei [2, 6-9] indicate the need for a study of the characteristics of its action within single nuclear formations. If injected intravascularly serotonin is known to affect the sympathetic and parasympathetic divisions of the autonomic nervous system [i, 3, 5], whereby it participates in the(More)