L. S. Godlevskii

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Studies in Wistar rats in conditions of free behavior showed that low-frequency stimulation of the paleocerebellar cortex (nodulus, uvula) (10–12 Hz, 0.5 msec) was accompanied by activation of spike discharges induced by systematic application of benzylpenicillin sodium (3,000,000 IU/kg). Facilitation of the formation of ictal discharges was also seen.(More)
Data are presented in this paper on the influence of the delta-sleep-inducing peptide (DSIP) on various forms of convulsive activity. The capacity of this peptide to suppress convulsive activity in foci created in the cerebral cortex by the application of strychnine has been demonstrated in experiments on cats. It has been established in experiments on rats(More)
Acute experiments were performed on rats to produce a model of chronic epileptic activity - pharmacological kindling by repeated doses of picrotoxin (1.0–1.2 mg/kg, i.p.). During the early period following kindling (24 h from the last dose of epileptogen), animals showed decreases in measures of investigative behavior as measured in an open field test,(More)
The action of diazepam (0.5 and 1.5 mg/kg, i.v.) on epileptic foci induced by benzylpenicillin (10,000 IU/ml) applications onto thesulc. sygmoid post. was studied in acute experiments on cats. It is demonstrated that under conditions of preceding electrical stimulation of the cerebellar vermis, diazepam more significantly suppresses the epileptic activity(More)
Acute experiments on rats showed that the ED100 of NMDA for induction of clonic convulsions was 0.53 μg, while the ED100 of NMDA for inducing tonic extension of the forelimbs was 5.02 μg/animal. Determination of these parameters after administration of delta-sleep-inducing peptide (100 μg/kg, i.p.) revealed 2.3- and 4.46-fold increases. These results(More)
Picrotoxin-induced kindling was shown to suppress the blastogenic response to bacterial lipopolysaccharide and phytogemagglutinin in male Wistar rats. The delta-sleep-inducing peptide as well as carbamazepine prevented the epileptogenic effects of picrotoxin. Carbamazepine was also effective against decreasing of phytogemagglutinin-induced blastogenic(More)
Experimental studies were carried out to investigate the neuroprotective effects of delta-sleep-inducing peptide in animals with cerebral ischemia induced by bilateral compression of both carotid arteries, and to compare the efficacy of this peptide with that of MK-801. These studies led to the conclusion that the peptide had pronounced anti-ischemic(More)
Effects of different doses of nicotinamide, pantogam, pnenazepam, and their combined actions on generalized seizures induced by pentylenetetrazole (60-100 mg/kg) were studied in acute experiments on mice. It was shown that pantogam (500 mg/kg) doubled the latent period of seizures, considerably attenuated the intensity of attacks and lethality, whereas(More)
Intracerebroventricular injection of recombinant human interferon-2alpha (100-500 U/rat) decreased the mean effective dose of corasol inducing clonic convulsions in 50% kindled Wistar rats. This effect was more pronounced in delayed periods of kindling and was accompanied by enhancement of epileptiform signs on EEG.
In experiments on rats subjected to a procedure of corazole kindling with the development of antiepileptic drug-resistant seizures, we found that manifestations of resistance were suppressed under conditions of feeding the rats with a ketogenic diet (KD) including 80% lipids and 16.6% proteins. Against the background of using this diet, such means as(More)