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  • Ester Carballo-Jane, L S Gerckens, +9 authors Michael J. Forrest
  • Chemistry, Medicine
  • Journal of pharmacological and toxicological…
  • 2007 (First Publication: 1 November 2007)
  • INTRODUCTION GPR109A is the receptor mediating both the antilipolytic and vasodilatory effects of nicotinic acid. In order to develop agonists for GPR109A with improved therapeutic indices we haveContinue Reading
  • Charles J Gill, J. J. Jackson, +5 authors Haim Rosen
  • Biology, Medicine
  • Antimicrobial agents and chemotherapy
  • 1998 (First Publication: 1 August 1998)
  • MK-826 (formerly L-749,345), is a potent 1-beta-methyl carbapenem with a long half-life and broad spectrum of activity. This compound is presently in phase-II clinical trials. Its activity against aContinue Reading