L. S. Gal'braikh

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Effect of commercially available preparations of chitosan sulfate on the total lipolytic activity was studied in rabbit blood. Chitosan sulfates, administered per os or intravenously, proved to be highly effective activators of lipolytic enzymes. The most distinct efficiency exhibited preparations with molecular mass of 60-120 x 10(3) and the rate of(More)
In recent years, the assortment of wound-healing dressings has increased due to the appearance of essentially new materials based on synthetic and natural polymers. In contrast to the conventional gauze, the novel dressing materials perform several functions, the most important of these being wound healing. For this purpose, the base material contains one(More)
We studied anticoagulant effects of combined administration of heparin (H) and chitosan sulfate ether (CS) (specific activity 20 UE/mg) in the ratio 1 : 1. CS enhanced anticoagulant activity of heparin in rabbits by a factor of 1.95 +/- 0.15. The intravenous injection of the mixture in a dose of 0.5 mg(H)/kg + 0.5 mg(CS)/kg and heparin injection in a dose(More)
In recent years, considerable progress has been achieved in the development of wound-healing dressings having a combined biological effect [1]. A pathogenetically justified approach to the treatment of septic wounds consists in using dressings possessing both proteolytic and antimicrobial activity. This significantly accelerates healing, reduces the(More)
The possibility of enzymatic hydrolysis of chitosan was shown. The optimum conditions for the process are sodium acetate buffer pH 6.0, 37°C, 24 h, and a chitosan sulfate–protein volume ratio of 500 : 1 in the enzyme preparation. During hydrolysis, the intrinsic viscosity of chitosan sulfate solution decreased by a factor of 2.7.
1. Derivatives of cellulose containing 3, 6-anhydro rings have been synthesized by the following route: cellulose → 6-O-tritylcellulose → 6-O-trityl-2, 3-di-O-acetylcellulose → 2, 3-di-O-acetylcellulose →6-O-tosyl-2, 3-di-O-acetylcellulose → 3, 6-anhydrocellulose. 2. The composition of the 3, 6-anhydrocellulose has been studied by exhaustive acetylation,(More)
Rabbit experiments have revealed that there is a relationship between the chemical structure and anticoagulative effects of polysulfated chitosan derivatives. Sixteen chitosan polymers with a polarization rate of 71 to 547 and substitution by sulfur from 0.62 to 1.86 which were intravenously injected showed heparin-like action. The anticoagulant activity of(More)
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