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BACKGROUND The purpose of this study was to determine whether abnormal Ca2+ release through ryanodine-sensitive Ca2+ channels in the sarcoplasmic reticulum might contribute to the abnormal [Ca2+]i homeostasis that has been described in failing human myocardium. METHODS AND RESULTS Occupancy of low-affinity ryanodine binding sites on ryanodine-sensitive(More)
The optimal type and duration of antifungal therapy for localized aspergillosis in cardiac transplant recipients is unclear. We report the case of a patient who had persistent invasive pulmonary aspergillosis despite prolonged treatment with amphotericin B. A combined approach using antifungal therapy and surgery appears effective for localized pulmonary(More)
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