L. Pereira Leite

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Nonspecific esophageal motility disorder (NEMD) is a vague category used to include patients with poorly defined esophageal contraction abnormalities. The criteria include "ineffective" contraction waves, ie, peristaltic waves that are either of low amplitude or are not transmitted. The aim of this study was to identify the prevalence of ineffective(More)
UNLABELLED Patients with gastroesophageal reflux disease (GERD) who remain symptomatic despite receiving a moderate dose of a proton pump inhibitor need accurate assessment to determine who will respond to high doses of the drug or even need surgery. AIM To determine if prolonged ambulatory pH monitoring performed in patients with persistent symptoms(More)
Cardiotocography (CTG) lacks reliability and reproducibility and these problems are believed to be overcome by computer analysis. In this article we describe a system developed for routine clinical automated CTG analysis based on a low cost personal computer. Presently the system has processed 70 ten minute tracings. Fetal heart rate baseline,(More)
OBJECTIVE To identify patients with gastroesophageal reflux disease (GERD) who, despite omeprazole 20 mg b.i.d., demonstrate continued abnormal gastric acid secretion. METHODS Eighty-eight patients with GERD completed ambulatory gastric and esophageal pH monitoring for persistent symptoms on omeprazole 20 mg b.i.d.. Seventeen (19%) demonstrated abnormal(More)
OBJECT To assess the effect of acid infusion on the response of normal subjects to progressive intra-oesophageal balloon distension (IOBD). METHODS Twenty-one volunteers underwent slow IOBD. Subjects were asked to indicate the first perception of sensation (S1) and the onset of pain (S2), balloon volumes being recorded at both points. A 15-min infusion of(More)
OBJECTIVES To investigate both perinatal and postneonatal morbidity and mortality in fetuses with absent or reversed end-diastolic flow (ARED flow) in the umbilical artery. STUDY DESIGN A 5 year prospective follow-up of 88 fetuses with ARED flow. RESULTS Sixteen stillbirths, 16 neonatal deaths, six postneonatal deaths and one death at 2 years of age(More)
OBJECTIVE To determine the effect of decreasing time intervals between acid exposures on the sensitivity of the esophageal mucosa. METHODS Ten healthy subjects with no history of gastroesophageal reflux disease who were symptomatic during a modified Bernstein acid infusion test were recruited for the study. Hydrochloric acid solutions of pH 3, 2, and 1(More)
The relationship between the birth weights of the mother and her infant was evaluated in a sample of 106 women consecutively delivered of a single live birth. Women were included in the study if their birth weight was available in hospital files or from another reliable source. Women that were themselves a twin or had diseases complicated the course of the(More)
OBJECTIVE Octreotide, a somatostatin analog, is antinociceptive and increases perception threshold in the rectum. The aim of this study was to determine whether octreotide alters esophageal sensory thresholds and cortical evoked potentials (CEPs) resulting from intraesophageal balloon distension. METHODS Twelve healthy volunteers (six men and six women,(More)