L. Perdrix

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S 5682 is a purified flavonoid fraction containing 90% diosmin (flavone derivative) and 10% hesperidin (flavanone derivative). In this study the scavenging properties of S 5682 on active oxygen radicals were demonstrated in vivo and in vitro. The activity of intravenous S 5682 was evaluated in the rat by measuring the degree of hyperglycemia provoked by an(More)
BACKGROUND Early detection of diastolic dysfunction is crucial for patients with incipient heart failure. Although this evaluation could be performed from phase-contrast (PC) cardiovascular magnetic resonance (CMR) data, its usefulness in clinical routine is not yet established, mainly because the interpretation of such data remains mostly based on manual(More)
BACKGROUND An accurate assessment of left ventricular (LV) mass is important for the detection of LV hypertrophy. AIMS To assess the accuracy of four echocardiographic imaging modalities for assessing LV mass compared with cardiac magnetic resonance (CMR). METHODS We prospectively studied 40 consecutive patients, who underwent an echocardiographic(More)
The effect of Daflon 500 mg, consisting of 90% diosmin and 10% hesperidin, on bovine veins and lymphatic vessels was shown. The recording of mechanical tension on metacarpal vein rings demonstrated a dose-effect relationship with an ED50 of 0.5 X 10(-6) M. This effect observed on isolated organs, is close to the tonic effect of Daflon 500 mg observed in(More)
BACKGROUND Accurate quantification of aortic valve stenosis (AVS) is needed for relevant management decisions. However, transthoracic Doppler echocardiography (TTE) remains inconclusive in a significant number of patients. Previous studies demonstrated the usefulness of phase-contrast cardiovascular magnetic resonance (PC-CMR) in noninvasive AVS evaluation.(More)
BACKGROUND The effect of statins on the prevention of cardiovascular events is well-established. However, a recent controversy in France questioned the value of statins, especially in primary prevention. AIMS To evaluate the impact of this controversy on patient adherence to statin therapy and its potential clinical impact. METHODS All patients on(More)
Early detection of diastolic dysfunction is crucial for patients with incipient heart failure. Our goal was to develop a robust process to automatically estimate diastolic parameters from phase-contrast cardiovascular magnetic resonance (PC-CMR) data and to test their ability to characterize left ventricular (LV) dysfunction. We studied 53 subjects (35(More)
OBJECTIVES Our objectives were to assess the ability of phasecontrast MRI (PC-MRI) to detect sub-clinical age-related variations of left ventricular (LV) diastolic parameters and thus to provide age-related reference ranges currently available for echocardiography but not for MRI-PC, and to identify independent associates of such variations. METHODS We(More)