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The B cell functional response following ligation of surface (s) IgM is dependent upon the differentiation stage of the population studied: cross-linking sIgM promotes proliferation of resting tonsillar follicular mantle (FM) B lymphocytes but induces apoptosis in the susceptible Epstein-Barr virus genome-negative Burkitt lymphoma (BL) cell line Ramos(More)
Signals transduced through CD40 rescue cells of the Ramos-Burkitt lymphoma (Ramos-BL) B cell line from surface immunoglobulin M (sIgM)-triggered growth arrest and apoptosis. This study investigates whether protein tyrosine kinase (PTK) activity and tyrosine phosphorylation on p95(vav) and on the p85 regulatory subunit of phosphatidylinositol 3-kinase (PI3(More)
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