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Germline mutations of the hMSH2 gene are responsible for many cases of hereditary nonpolyposis colorectal cancer. While screening for hMSH2 gene mutations in hereditary nonpolyposis colorectal cancer kindreds, we observed that a previously reported germline mutation is in fact a common, alternatively spliced variant in the population. Using RT-PCR and the(More)
BACKGROUND Src family kinases control multiple cancer cell properties including cell cycle progression, survival, and metastasis. Recent studies suggest that the Src inhibitor dasatinib blocks these critical cancer cell functions. METHODS Because the molecular mechanism of action of dasatinib in breast cancers has not been investigated, we evaluated the(More)
The synovial fluid or group II secretory phospholipase A2 (sPLA2) has been implicated in various inflammatory processes and has been shown to release arachidonic acid for prostaglandin biosynthesis. In human colorectal cancer, both arachidonic acid and eicosanoid levels are elevated. Recently, sPLA2 has been identified as a candidate gene that modifies the(More)
OBJECTIVE This study aimed to assess the benefits and risks of conscious sedation with midazolam and dezocine in diagnostic flexible bronchoscopy (FB). PATIENTS AND METHODS This prospective case control study enrolled 40 non-sedated and 40 sedated subjects who underwent diagnostic FB. All received the standard upper airway preparation, while sedated(More)
We present a study of a high spatial resolution raster acquired on-disk with the SUMER (Solar Ultraviolet Measurements of Emitted Radiation) grating spectrograph on SoHO (the Solar and Heliospheric Observatory) in a polar Coronal Hole (CH) region. We analyse two EUV emission lines, representing the properties of solar plasma in the low transition region(More)
We present a study the dynamic properties of EUV spicules. The selected data were obtained as time series in polar coronal holes by SUMER/SOHO. The short exposure time and the almost fixed position allow the analysis of the spicule properties such as: occurrence, lifetime, Doppler velocity, etc. Our data reveal that spicules occur repeatedly at the same(More)
Here we study the dynamic properties of EUV spicules seen at the solar limb. The selected data were obtained as time series in polar coronal holes by SUMER/SoHO. The short exposure time and the almost fixed position of the spectrometer’s slit allow the analysis of spicule properties such as occurrence, lifetime and Doppler velocity. Our data reveal that(More)
OBJECTIVE Pancreatic cancer is one of the leading causes of death from cancer in European countries and the United States. This study sought to investigate the effects of aconitine, a well-known aconitum plant-produced toxin, on pancreatic cancer cell growth and apoptosis and to explore the potential mechanisms. MATERIALS AND METHODS In this study,(More)