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The microiontophoretic application of morphine to single globus pallidus neurons in morphine naive rats resulted in a depression of both spontaneous and glutamate-evoked firing of these neurons. Seventy percent of all pallidal neurons on which morphine was tested exhibited some degree of depression of neuronal discharge; no excitatory effect ws observed to(More)
Surgically implanted osmotic minipumps were used to apply dye or [3H]-muscimol locally to the nucleus ventralis lateralis or globus pallidus of the cat. Extent of distribution of dye or radioactivity was measured from the site of application. A uniform distribution (1.2-2.5 mm) of dye or radioactivity was found lateral, ventral, and posterior to the(More)
Postsynaptic potentials, evoked by lingual or hypoglossal nerve stimulation, were recorded from hypoglossal motoneurons of the cat with glass microelectrodes. Lingual nerve-evoked inhibitory postsynaptic potentials (LIPSPs) were recorded in 98% of hypoglossal motoneurons. Hypoglossal nerve stimulation caused a hyperpolarizing potential following the(More)
The effects of iontophoretically applied substance P (SP) and eledoisin-related peptide (ERP) on the extracellularly recorded activity of spontaneous or D,L-homocysteic acid (DLH)-driven thoracic (T7-T8) spinal neurons, identified by orthodromic activation by the greater splanchnic nerve, were examined in chloralose/urethane anesthetized cats. Of 24 neurons(More)