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Endothelin-1 (Et-1) stimulated DNA synthesis in placental fibroblasts in a dose-dependent manner, as measured by [3H]thymidine incorporation (ED50, 0.2-0.3 ng/mL). Insulin-like growth factor-I (IGF-I) interacted synergistically with Et-1 to potentiate the stimulation of DNA synthesis. Additionally, Et-1 stimulated the turnover of phosphoinositides in a(More)
Aromatase synthesizes estrogen from androgen precursors. To better understand the role of estrogen in skeletal metabolism and growth, we have assessed long bone growth and histomorphometry in aromatase-deficient (ArKO) mice. The age range for the animals was 5-7 months. At this age mice have already achieved peak bone density but continue slow bone growth.(More)
Estrogens are important for normal bone growth and metabolism. The mechanisms are incompletely understood. Thus, we have undertaken characterization of the skeletal phenotype of aromatase (ArKO) deficient mice. No abnormalities have been noted in skeletal patterning in newborns. Adult ArKO mice show decreased femur length and decreased peak Bone Mineral(More)
Endothelin-1 (ET-1) mRNA is expressed by the human placenta in a developmentally regulated manner and has been shown to stimulate the growth of placental mesenchymal cells. The ability of placental fibroblasts to express preproET-1 mRNA was studied to determine if ET-1 could potentially participate via autocrine mechanisms in the proliferation of placental(More)
The c-fos proto-oncogene is found to be overexpressed at least 30-fold in SMS-SB, a pre-B leukemic cell line compared to other cell types. No gross alteration of the c-fos gene structure in SMS-SB cells can be detected by karyotypic or Southern analyses. C-fos in SMS-SB cells can still be induced by serum, TPA and the calcium ionophore, A23187, and(More)
Preterm, human, placental fibroblasts exhibit growth rates, in vitro, that vary with gestational age. The observed increase in proliferation rate is associated with enhanced mitogenic responsiveness to IGF-I. IGFBPs can either potentiate or inhibit IGF action at the cellular level. The production of IGFBPs by placental fibroblasts was studied as potential(More)
2014 An analysis is performed concerning the application of the available theoretical interpretations in analysing the new experimental data obtained in the study of the early stages of the cw CO2 laser oxidation of copper targets. J. Physique Lett. 45 (1984) L-737 L-740 15 JUILLET 1984, Classification Physics Abstracts 81.60 42.60