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The response to growth factor stimulation was evaluated in clonally derived rat bladder carcinoma cell lines, ranging from nontumorigenic to tumorigenic and metastatic, in athymic nude mice. In the nontumorigenic cell line D44c, epidermal growth factor (EGF)/transforming growth factor (TGF) alpha weakly stimulated anchorage-dependent, but not -independent,(More)
We examined 60 cases of human urothelial carcinomas (27 superficial and 33 deeply invasive) for the frequency of p53 gene mutations. Forty-two cases were analyzed by both the immunohistochemical and the single-strand conformation polymorphism (SSCP) methods, and the remaining 18 cases were assayed by SSCP alone. For the latter assay, exons 4 to 8 were(More)
An undifferentiated deeply invasive ureteral carcinoma with syncytiotrophoblastic differentiation was analyzed for the synthesis of human chorionic gonadotropin beta-subunit by immunohistochemistry and Northern blot analysis. Human chorionic gonadotropin beta-subunit was localized immunohistochemically to syncytiotrophoblastic cells and scattered(More)
In this study, we attempted to find a gene or genes which were differentially expressed between a non-tumorigenic rat bladder cell line and a highly tumorigenic/metastatic bladder carcinoma cell line that was derived from the former after treatment in vitro with N-methyl-N-nitrosourea. We cloned a rat keratin 5 cDNA by a differential hybridization technique(More)
The bioactive glucoside, paeoniflorin, has been shown to have an anti-inflammatory effect on ischemic brain injury. In this study, we aimed to investigate the ability of paeoniflorin to regulate the expression of NLRP1 and NLRP3 inflammasomes in rat hippocampal slices. Different concentrations of paeoniflorin were applied to oxygenglucose-deprived(More)
Numerous studies have reported a correlation between the production of gelatinases A and B by cancer cells and invasive and metastatic potential. It has been suggested that the expression of gelatinase A (72-kDa type IV collagenase) is associated more closely with the metastatic phenotype of malignant cells in vitro and in vivo than that of gelatinase B(More)
We established 5 rat bladder cell lines (MYU3L, MYU4, MYU6s, MYKU1L and MYP3). EGF stimulated DNA synthesis of all the cells in monolayer culture, regardless of the number of EGF receptors. In soft agar, only MYU3L formed colonies, and EGF enhanced their growth. However, EGF did not induce the other cells to grow in soft agar. In contrast, TGF-beta 1(More)
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