L N Nuñez

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Comparing effects of the horizontal-vertical illusion on grip scaling and judgment: relative versus absolute, not perception versus action.

Peter M. Vishton, Judy Rea, Jennifer E Cutting, L N Nuñez
Journal of experimental psychology. Human…
1999

The discovery that the prehension component of an open-loop, two-fingered reach is largely immune to certain salient pictorial illusions has been used to suggest that humans possess 2 distinct visual… (More)

Antitumoral activity of the mithralog EC-8042 in triple negative breast cancer linked to cell cycle arrest in G2

Atanasio Pandiella, Francisco Morís, Alberto Ocaña, L N Nuñez, Juan Carlos Montero
Oncotarget
2015

Triple negative breast cancer (TNBC) is an aggressive form of breast cancer. Despite response to chemotherapy, relapses are frequent and resistance to available treatments is often observed in the… (More)

Pleiotropic Anti-Angiogenic and Anti-Oncogenic Activities of the Novel Mithralog Demycarosyl-3D-ß-D-Digitoxosyl-Mithramycin SK (EC-8042)

Azahara Fernández-Guizán, Alejandro López-Soto, +6 authors Maria Cristina Vinci
PloS one
2015

Demycarosyl-3D-ß-D-digitoxosyl-mithramycin SK (DIG-MSK) is a recently isolated analogue of mithramycin A (MTA) that showed differences with MTA in the DNA binding strength and selectivity. These… (More)

Phospho-kinase profile of colorectal tumors guides in the selection of multi-kinase inhibitors.

Gemma Serrano-Heras, María Dolores Cuenca-López, +6 authors Alberto Ocaña
Oncotarget
2015

Protein kinases play a central role in the oncogenesis of colorectal tumors and are attractive druggable targets. Detection of activated kinases within a tumor could open avenues for drug selection… (More)

The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription.

Azahara Fernández-Guizán, Sylvia Mansilla, +5 authors José Santos Portugal
Chemico-biological interactions
2014

DIG-MSK (demycarosyl-3D-β-D-digitoxosyl-mithramycin SK) is a recently isolated compound of the mithramycin family of antitumor antibiotics, which includes mithramycin A (MTA) and mithramycin SK… (More)

Novel mithramycins abrogate the involvement of protein factors in the transcription of cell cycle control genes.

Carolina Vizcaíno, Sylvia Mansilla, +4 authors José Santos Portugal
Biochemical pharmacology
2012

The effects of mithramycin SK (MSK) and demycarosyl-3D-β-D-digitoxosyl-mithramycin SK (DIG-MSK; EC-8042), two novel analogs of the antitumor antibiotic mithramycin A, on gene transcription were… (More)

Modulation of the Activity of Sp Transcription Factors by Mithramycin Analogues as a New Strategy for Treatment of Metastatic Prostate Cancer

Anastasia Malek, L N Nuñez, +5 authors Carlo Vittorio Catapano
PloS one
2012

Deregulated activity of transcription factors (TFs) of the Sp/KLF family, like Sp1, Sp3 and Sp4, and consequent over-expression of Sp-regulated genes occur frequently in human cancers. This provides… (More)

Cytotoxic effects of mithramycin DIG-MSK can depend on the rise of autophagy.

Carolina Vizcaíno, Maria A Rodríguez-Sánchez, L N Nuñez, Francisco Morís, José Santos Portugal
Toxicology in vitro : an international journal…
2015

DIG-MSK (demycarosil-3D-β-D-digitoxosyl mithramycin SK; EC-8042), a novel analogue of mithramycin A, induced autophagy in HCT116 human colon carcinoma and, to a lesser extent, in A2780 human ovarian… (More)

Inhibition of SP1 by the mithramycin analog EC-8042 efficiently targets tumor initiating cells in sarcoma

Juan Tornin, Lucia Martinez-Cruzado, +10 authors René Rodríguez
Oncotarget
2016

Tumor initiating cells (TICs), responsible for tumor initiation, and cancer stem cells (CSCs), responsible for tumor expansion and propagation, are often resistant to chemotherapeutic agents. To find… (More)

Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor.

Christy L. Osgood, Nichole K. Maloney, +17 authors Patrick J. Grohar
Clinical cancer research : an official journal of…
2016

PURPOSE The goal of this study was to identify second-generation mithramycin analogues that better target the EWS-FLI1 transcription factor for Ewing sarcoma. We previously established mithramycin as… (More)

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