We developed a method for evaluation of membrane permeability for water based on the analysis of osmotic permeability profiles of red blood cells. Deformability of completely spherulated erythrocytes changed in a dose-dependent manner during formation of artificial water pores (by nystatin) and blocking (by HgCl2) of the existing ones.
In experiments on Wistar rats and guinea pigs, dynamics of blood hematological parameters and of erythrocyte deformability index (DI) was studied from birth to the 3-month age. In rats, significant changes were revealed in the picture of blood for the first month of postnatal ontogenesis. The number of erythrocytes and leukocytes sharply increased, the… (More)