L. N. Coyle

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We consider a new numerical method developed by Barraquand and Martineau for the pricing of American securities where the payoff depends on several sources of uncertainty. This method utilizes Monte Carlo simulation and is referred to as Stratified State Aggregation along the Payoff (SSAP). Since there are no other methods that so effectively reduce the(More)
Current in vitro approaches to cardiac safety testing typically focus on mechanistic ion channel testing to predict in vivo proarrhythmic potential. Outside of the Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative, structural and functional cardiotoxicity related to chronic dosing effects are of great concern as these effects can impact compound(More)
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