L. N. Cothran

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Atrial natriuretic peptide (ANP) represents a family of related peptides originally isolated from cardiac atria that have potent natriuretic, diuretic, and vasorelaxant properties. ANP has previously been localized in neurons of the rat brain in regions subserving cardiovascular functions and fluid/electrolyte balance and has been localized in astroglia of(More)
Inflation-extension experiments were carried out on segments of the descending thoracic aortas from 4 normotensive and 4 hypertensive dogs rendered hypertensive using either unilateral or bilateral renal artery constriction. Intravascular pressures up to 200 mm Hg and axial forces up to 200 g were used. The external diameter of the segment and the distance(More)
The short-axis area-length method for the estimation of left ventricular mass (LVM) and volume was validated in 24 formaldehyde-fixed canine hearts, using the truncated ellipsoid model. Estimates of the short-axis muscle area were highly correlated with directly measured values (R = 0.92; P less than 0.001). Similarly, LVM calculated using the area-length(More)
Although vasomotor activity in small pulmonary vessels has been studied extensively in the past, using the concept of resistance to flow, information on the distensibility of these vessels is very sparse. In an attempt to reduce this deficit, we adapted a theoretical method developed for small systemic vessels, to estimate distensibility of pulmonary(More)
The present study describes and illustrates a noninvasive method for computing extensibility of the 'resistance vessels', from an experimentally obtained resistance vs transmural pressure plot, in a maximally dilated vascular bed of man. Limb blood flow was measured plethysmographically following 10 min of arterial occlusion, and blood pressure was measured(More)
Using sonomicrometric and indwelling pressure transducers, 16 healthy, normotensive dogs were prepared for semicontinuous monitoring of left ventricular (LV) mass, volumes, pressures, flows and wall tension (W Ten), aortic pressure (AP), total peripheral resistance (TPR), and indices of myocardial contractility. After a period of control measurements,(More)
Hypertension was produced in anesthetized and conscious dogs when cerebral perfusion was reduced. It lasted up to 19 days in chronic studies, was not abolished by carotid sinus denervation nor with beta receptor blockade, but was absent after removal of brachiocephalic artery constriction (BCAC). The cardiovascular features of this “neurogenic hypertension”(More)
AIM To calculate the compliance of resistance vessels. METHODS Pressure-flow data (plethysmographic and sphygmomanometric) were obtained non-invasively from six normal and six hypertensive subjects, and the results were compared with similar data obtained previously from large blood vessels. The parameter used to represent compliance was extensibility(More)
A simple theoretical approach is presented for estimating vascular distensibility of small blood vessels from noninvasively obtained pressure-flow data in the hand and forearm of human subjects. To the extent that Poiseuille's law applies to blood flow in these vascular beds, conductance (the reciprocal of vascular resistance) can be calculated from these(More)
A baboon was exchange-transfused with sickle cell anemia patients' blood. The animal died suddenly, and postmortem examination showed widespread red cell sequestration, particularly in the spleen and liver. The clinical and pathological findings were similar to those in children with sickle cell anemia who die of acute splenic sequestration syndrome. A(More)
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