L. N. Brovkina

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A monoclonal antibody (IgG) has been produced that binds to DNA modified with osmium tetroxide and 2,2'-bipyridine and does not react with unmodified DNA and modified or unmodified RNA and proteins. The reaction specificity is due to the presence of the modified deoxythymidine residue within the epitope. Possible use of the antibody for studies of DNA(More)
The influence of charged polymers on the reaction of immunoglobulins from human lupus sera with cellular proteins was investigated in this study. Through immunoblotting it was shown that polyanions (dextran sulfate, heparin, polyinosinic acid) and polylysine inhibited autoantibody binding to several polypeptides of different molecular mass. Using(More)
In systemic lupus erythematosus (SLE), scleroderma, and other collagenoses, autoantibodies to different forms of DNA and RNA, to ribonucleoproteins, to proteins of the nucleus, ribosomes, cytoskeleton, and so on, are often found in the patients' serum [2, 10]. Crossed reactions with biopolymers carrying negatively charged groups have been described for many(More)
Effect of polyanions on reaction of the Ig from sera of patients with systemic lupus erythematosus and scleroderma with cellular proteins was studied by immunoblotting. It has been shown that dextran sulfate, heparin, denatured DNA and poly I inhibited the binding of autoantibodies with some polypeptides. The molecular weight of these antigens was(More)
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