L Mattucci-Schiavone

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Sprague-Dawley rats received taurine intracerebroventricularly (i.c.v.) 30 min prior to ethanol (4 g/kg, i.p.). The duration of ethanol-induced sleep time was increased with taurine at doses of 7.5, 14.0 and 25.0 mumol/kg. In another experiment, TAG (a taurine antagonist, i.c.v.) was given 5 min prior to taurine (i.c.v.) and ethanol was administered 30 min(More)
In male Sprague-Dawley rats the acute effect of ethanol administration (1.0, 2.0, or 3.0 g/kg, IP) on motor coordination was measured by the aerial righting reflex. Ethanol in doses of 2.0 and 3.0 g/kg produced significant impairment of motor coordination with corresponding elevated blood ethanol levels. The rate of ethanol dissappearance from the blood was(More)
It was demonstrated that the aerial righting reflex can be used as an index of acute ethanol-induced impairment of motor coordination in rats, and was found to directly correlate with blood ethanol content from the infraorbital plexus. A study of ethanol within the blood and its distribution in brain regions showed that the ethanol content of orbital sinus(More)
In male Sprague-Dawley rats acute ethanol (1.0 and 2.0 g/kg) produced impairment of motor coordination and induced hypnosis (4.0 g/kg). Muscimol (1.25 mg/kg, IP) prior to ethanol administration enhanced motor impairment as measured by the aerial righting reflex. The rate of ethanol disappearance from the blood was unaltered by muscimol. Functional tolerance(More)
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