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Oxidized chylomicrons may be a metabolic factor involved in the injury of the arterial wall and may constitute a potential link between postprandial lipemia and atherogenesis. It was of interest to study the influence of dietary fatty acid composition on the oxidizability and subsequent cytotoxicity of chylomicrons on cultured cells. Human chylomicrons were(More)
Human endothelial cells (ECs) grown under standard conditions are able to generate a basal level of oxygen free radicals and induce progressive oxidation of LDLs. Inhibition of cell-mediated LDL oxidation by superoxide dismutase, EDTA, or desferrioxamine implicates a role for superoxide anion and/or transition metals in this process. The potential role of(More)
The ability of 17 beta-estradiol, progesterone, testosterone and cholesterol in preventing the cytotoxicity of oxidized LDL to cultured aortic bovine endothelial cells (BAEC) was tested and compared. The lipid peroxidation of LDL, promoted either by UV-C radiation, copper ions or cultured human lymphoblastoid cells, was inhibited in a dose-dependent manner(More)
Low-density lipoproteins (LDLs), treated by UV-C radiations under conditions permitting mildly oxidized LDL (6 +/- 2 nmol TBARS/mg apoB, without major structural or functional alteration of apoB), have been used for studying their cytotoxicity to cultured bovine aortic endothelial cells and the cytoprotective effect of various analogs of alpha-tocopherol.(More)
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