L. M. Sharagina

  • Citations Per Year
Learn More
P-insertion mutations were obtained and localized byin situ methods at the agnostic gene (agn: 1–38.9; 11AB) inDrosophila. All agn mutants showed a wide spectrum of pleiotropic effects: an EMS-induced mutation of the agn-ts398 improved the ability to develop a conditioned defensive response and increased the activity of cAMP metabolic enzymes; spontaneous(More)
The activities of general phosphodiesterase and its Ca(2+)-calmodulin-independent from (PDE-1) were studied in strains mutant for the agnostic gene and in the strain Canton S. Enzyme activity was determined in males and homo- and hemizygous females of four strains. It was found that mutation at the agnostic gene resulted in increased PDE-1 activity. This(More)
The ts-mutations of the agnostic gene either increased or decreased the activity of the AC and PDE. A chromosomal deficiency in the 11B region failed to complement with the agnostic behavioral defect like agn P29 and P40, led to an increased proportion of the PDE-1 in total PDE and to the structural defects in the central complex thus indicating that the P(More)
The content and intensity of metabolism of phosphate groups of various phospholipids (phosphatidylcholines, monophophoinositides, aminophospholipids) were studied in homogenate, microsomes, and cytosol of the rat brain under normal conditions and in hypoxic hypoxia (240 mm Hg). The concentration of phospholipids per milligram protein was found to be highest(More)
Bilateral ligation of common carotid arteries sharply decreases volume blood flow and oxygen consumption in the cortex, in diencephalon and midbrain whereas inducing no changes in the cerebellum and medulla oblongata. The same is true for intensity of metabolism of both total and separate fractions of phospholipids. This suggests that the changes of(More)
This article provides a short summary of studies carried out on mutant Drosophila with defects in learning ability, including our own experimental data on the role of the tryptophan oxygenase gene (this is a key enzyme, and is the first enzyme in the tryptophan-ommochrome metabolic pathway) in the inherited determination of learning ability and memory in(More)
The rate of phospholipid turnover in brain subcellular fractions differ from that in the liver tissue. Hypoxia of medium severity (pressure chamber 240 mm Hg) influences neither the content nor the turnover rate of phospholipids in liver subcellular fractions. Meanwhile in brain subcellular fractions, it results in a decreased phospholipid turnover rate.(More)
The content and the intensity of metabolism of various phospholipid groups (phosphatidylcholines, monophosphoinositides, aminophospholipids) was studied in the homogenate, microsomes, and cytozol of the rat brain under normal conditions and in hypoxic hypoxia (240 mm Hg). Phospholipid content per 1 mg of protein was the highest in the microsomes, and the(More)