L L Gragowski

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When murine (C57BL/6) bone marrow cells are cultivated with WEHI-3 conditioned media, a source of megakaryocyte-colony-stimulating activity (Mk-CSA), and phorbol myristate acetate (PMA), a previously undetected population of megakaryocyte (Mk) progenitor cells is observed. These new Mk colonies are reminiscent of erythroid bursts, in that they contain large(More)
Little information exists concerning differing levels of regulation occurring during human megakaryocyte development. We hypothesize that megakaryocytic proliferation and maturation is controlled by two, synergistic regulatory factors. One, megakaryocyte colony-stimulating activity, is an obligate requirement for colony formation and drives the development(More)
Little information exists concerning the role of guanine nucleotide-binding proteins (GNBP) in hematopoietic progenitor cell proliferation. We hypothesized that GNBP-mediated activation of adenylate cyclase plays an important role in factor-driven hematopoietic cell proliferation. Using cholera toxin and other probes of the cyclase system, we observe that(More)
Replication defective Abelson murine leukemia virus (A-MuLV) induces a non-thymic lymphoma in vivo and transforms both hematopoietic and fibroblastic cells in vitro. In vivo leukemogenicity and the efficiency of in vitro transformation of hematopoietic cells by A-MuLV are known to be affected by the replication competent helper virus present in A-MuLV(More)
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