L. López-Aguado

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We have investigated the spatial map of tissue resistivity across CA1 layers in vivo, its modifications during repetitive orthodromic activity, and the influence of this factor on the shaping of population spikes. Measurement of tissue resistance was made by a high-spatial-resolution three-electrode method. A computer network of equivalent resistors aided(More)
Population spikes (PS) are built by the extracellular summation of action currents during synchronous action potential (AP) firing. In the hippocampal CA1, active dendritic invasion of APs ensures mixed contribution of somatic and dendritic currents to any extracellular location. We investigated the macroscopic and subcellular factors shaping the antidromic(More)
To study how the visual areas of the 2 hemispheres interact in processing visual stimuli we have recorded local field potentials in the callosally connected parts of areas 17 and 18 of the ferret during the presentation of 3 kinds of stimuli: 2.5 degrees squares flashed for 50 ms randomly in the visual field (S1), 4 full-field gratings differing in(More)
The mechanism of the propagation of spreading depression is unclear. Classical theories proposed a self-maintained cycle fed by elevated potassium and/or glutamate in the extracellular space. Earlier we found in vivo a characteristic oscillatory field activity that is synchronous in a strip of tissue ahead of the oncoming wave of neuron depolarization and(More)
Dendritic voltage-dependent currents and inhibition modulate the information flow between synaptic and decision areas. Subthreshold and spike currents are sequentially recruited by synaptic potentials in the apical shaft of pyramidal cells, which may also decide cell output. We studied the global role of proximal apical recruited currents on cell output in(More)
We studied the subcellular correlates of spreading depression (SD) in the CA1 rat hippocampus by combining intrasomatic and intradendritic recordings of pyramidal cells with extracellular DC and evoked field and unitary activity. The results demonstrate that during SD only specific parts of the dendritic membranes are deeply depolarized and electrically(More)
Action potentials (APs) in CA1 pyramidal cells propagate in different directions along the somatodendritic axis depending on the activation mode (synaptic or axonal). We studied how the geometrical inhomogeneities along the apical shaft, soma, and initial axon modulate the transmembrane current (I(m)) flow underlying APs, using model and experimental(More)
BACKGROUND The cortical representation of the visual field is split along the vertical midline, with the left and the right hemi-fields projecting to separate hemispheres. Connections between the visual areas of the two hemispheres are abundant near the representation of the visual midline. It was suggested that they re-establish the functional continuity(More)
During synchronous action potential (AP) firing of CA1 pyramidal cells, a population spike (PS) is recorded in the extracellular space, the amplitude of which is considered a reliable quantitative index of the population output. Because the AP can be actively conducted and differentially modulated along the soma and dendrites, the extracellular part of the(More)
Canals, S., I. Makarova, L. López-Aguado, C. Largo, J. M. Ibarz, and O. Herreras. Longitudinal depolarization gradients along the somatodendritic axis of CA1 pyramidal cells: a novel feature of spreading depression. J Neurophysiol 94: 943–951, 2005. First published March 30, 2005; doi:10.1152/jn.01145.2004. We studied the subcellular correlates of spreading(More)