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Baylisascaris procyonis roundworms, a parasite of raccoons, can infect humans, sometimes fatally. Parasite eggs can remain viable in raccoon latrines for years. To develop a management technique for parasite eggs, we tested anthelmintic baiting. The prevalence of eggs decreased at latrines, and larval infections decreased among intermediate hosts,(More)
Human demands on natural resources result in landscape changes that facilitate the emergence of disease. Most emerging diseases are zoonotic, and some of these pathogens play a role in the decline of vulnerable wildlife species. Baylisascaris procyonis, the common roundworm parasite of raccoons (Procyon lotor), is a well recognized zoonotic infection that(More)
BACKGROUND Neutrophils play an important role in the pathophysiology of RSV, though RSV does not appear to directly activate neutrophils in the lower airways. Therefore locally produced cytokines or other molecules released by virally-infected airway epithelial cells are likely responsible for recruiting and activating neutrophils. Heat shock proteins(More)
Rapid diagnosis of Lyme disease: flagellin gene–based nested polymerase chain reaction for identification of causative Borre-lia species. burgdorferi sigma54 is required for mam-malian infection and vector transmission but not for tick colonization.cott MJ. Fatal spirochetosis due to a relapsing fever-like Borrelia sp. in a northern spotted owl. Backyard(More)
Increased airway smooth muscle mass has been demonstrated in patients with bronchopulmonary dysplasia and asthma. These data highlight the need for a precise understanding of the events involved in airway smooth muscle mitogenesis. To that end, investigators have developed cell culture systems adopting tracheal and bronchial myocytes from different species.(More)
BACKGROUND Recognition of repeat unmethylated CpG motifs from bacterial DNA through Toll-like receptor (TLR-9) has been shown to induce interleukin (IL)-8 expression in immune cells. We sought to investigate the role of CpG oligodeoxynucleotides (ODN) on a human bronchial epithelial cells. METHODS RT-PCR and Western blot analysis were used to determine(More)
BACKGROUND Allergic asthma is on the rise in developed countries. A common characteristic of allergens is that they contain intrinsic protease activity, and many have been shown to activate protease-activated receptor (PAR)-2 in vitro. The role for PAR-2 in mediating allergic airway inflammation has not been assessed using a real world allergen. METHODS(More)
BACKGROUND A common characteristic of allergens is that they contain proteases that can activate protease-activated receptor (PAR-2); however the mechanism by which PAR-2 regulates allergic airway inflammation is unclear. METHODS Mice (wild type and PAR-2-deficient) were sensitized using German cockroach (GC) feces (frass), the isolated protease from GC(More)
Allergic diseases, which have reached epidemic proportions, are caused by inappropriate immune responses to a relatively small number of environmental proteins. The molecular basis for the propensity of specific proteins to promote maladaptive, allergic responses has been difficult to define. Recent data suggest that the ability of such proteins to promote(More)
BACKGROUND Cockroach exposure is a major risk factor for the development of asthma. Inhalation of fecal remnants (frass) is the likely sensitizing agent; however isolated frass has not been tested for its ability to induce experimental asthma in mice. METHODS Mice (Balb/c or C57Bl/6) were sensitized and challenged with GC frass or GC frass devoid of(More)