L Kh Allikmets

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The effects of neuropeptide Y Y(5) receptor antagonist (trans-naphtalene-1-sulphonic acid [4-[(4-amino-quinazolin-2-ylamino)-methyl]-cyclohexylmethyl]-amide hydrochloride; CGP71683A), on food intake, anxiety and locomotor activity were studied. CGP71683A (1-10 mg/kg, i.p.) dose-dependently decreased nocturnal and fasting-induced food intake. CGP71683A did(More)
Vocalization and aggressiveness reactions were evoked in experiments on male Wistar rats by means of electric shock stimulation. The influence of serotonin- and dopaminergic drugs was studied in parallel on emotional reactivity and serotonin metabolism. It has been found that l-tryptophane depresses while l-Dopa intensifies emotional reactivity and(More)
The motor depressant effects of caerulein and N-propylnorapomorphine (NPA) were compared in male mice. Caerulein (1-50 micrograms/kg SC) in a dose dependent manner depressed the exploratory activity, whereas NPA in lower doses (0.5-10 micrograms/kg SC) decreased the motor activity, but in higher doses (over 50 micrograms/kg) had stimulating effect on the(More)
In rats injected with kainic acid into the dorsal part of the caudate nucleus, the chronic treatment (for 20 days) with haloperidol (1 mg/kg) did not induce hypersensitivity of dopamine receptors. However, kainic acid produced no effect on hypersensitivity of the receptors after long-term administration of apomorphine (1 mg/kg). It is suggested that in the(More)
The experiments on male albino rats have shown that 15 days haloperidol (0.5 mg/kg) and raclopride (1 mg/kg) treatment, but not acute administration, causes the increase of density of sigma receptors in the brain. The number of phencyclidine receptors was also elevated, but this increase was not statistically evident. The behavioral effects of ketamine (5(More)
In experiments on rats and male mice the GABA derivatives fenibut, fepiron and the organosilicon compound N-methyl (3-trimethylsilil)pyrrolidone (IA) antagonized apomorphine sterotypy and aggressiveness. Fenibut and IA potentiated haloperidol catalepsy. Fenibut, fepiron, sodium hydroxybutyrate and IA also antagonized the effects of phenamine. The(More)
Behavioral and biochemical experiments on male albino mice have revealed similar effects after the cessation of repeated (15 days) haloperidol (0.5 mg/kg daily IP) and caerulein (0.1 mg/kg daily SC) treatment. Tolerance developed to the action of muscimol (a GABA-A agonist, 1 mg/kg IP), caerulein (a CCK-8 agonist, 15 micrograms/kg SC) and flumazenil (a(More)
The effects of physostigmine and m-cholinolytics on emotional reactivity, aggressiveness, exploratory behavior, along with simultaneous influence on the endogenous serotonin metabolism, enhanced by 1-tryptophan serotonin metabolism in the brain, were studied. Upon blocking the peripheral effects with methylatropine-physostigmine exerted a tranquillizing(More)
In experiments on male Wistar rats it was established that following a 10 days treatment with low doses (0.1 mg/kg) of apomorphine, tolerance developed to its sedative effects, while aggression to foot-shocks was markedly enhanced. Administration of apomorphine (0.5 mg/kg) and amphetamine (2.5 mg/kg) after chronic low dose apomorphine treatment revealed an(More)