L. Javier Hernández

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Numerous studies of the underlying causes of ageing have been attempted by examining diseases associated with premature ageing, such as Werner's syndrome and Hutchinson-Gilford progeria syndrome (HGPS). HGPS is a rare genetic disorder resulting in phenotypes suggestive of accelerated ageing, including shortened stature, craniofacial disproportion, very thin(More)
Laminopathies encompass a wide array of human diseases associated to scattered mutations along LMNA, a single gene encoding A-type lamins. How such genetic alterations translate to cellular defects and generate such diverse disease phenotypes remains enigmatic. Recent work has identified nuclear envelope proteins--emerin and the linker of the nucleoskeleton(More)
The high mortality rate from ovarian cancers can be attributed to late-stage diagnosis and lack of effective treatment. Despite enormous effort to develop better targeted therapies, platinum-based chemotherapy still remains the standard of care for ovarian cancer patients, and resistance occurs at a high rate. One of the rate limiting factors for(More)
Serous epithelial ovarian cancer (SEOC) is the most lethal gynecological cancer in the United States with disease recurrence being the major cause of morbidity and mortality. Despite recent advances in our understanding of the molecular mechanisms responsible for the development of SEOC, the survival rate for women with this disease has remained relatively(More)
Evidence suggests that small subpopulations of tumor cells maintain a unique self-renewing and differentiation capacity and may be responsible for tumor initiation and/or relapse. Clarifying the mechanisms by which these tumor-initiating cells (TICs) support tumor formation and progression could lead to the development of clinically favorable therapies.(More)
shRNA-mediated lethality screening is a useful tool to identify essential targets in cancer biology. Ovarian cancer (OC) is extremely heterogeneous and most cases are advanced stages at diagnosis. OC has a high response rate initially, but becomes resistant to standard chemotherapy. We previously employed high throughput global shRNA sensitization screens(More)
The small molecule NSC676914A was previously identified as an NF-κB inhibitor in TPA-stimulated HEK293 cells (Mol Can Ther 8:571-581, 2009). We hypothesized that this effect would also be seen in ovarian cancer cells, and serve as its mechanism of cytotoxicity. OVCAR3 and HEK293 cell lines stably containing a NF-κB luciferase reporter gene were generated.(More)
A new procedure based on partition of the unity has been developed to construct spatial approximation-prediction functions for discrete density functions. This Partition of the Unity Procedure (PUP) provides a family of approximation-prediction functions which depends on several parameters. In order to find the best function we have considered error(More)
The closed model category of exterior spaces, that contains the proper category, is a useful tool for the study of non compact spaces and manifolds. The notion of exterior weak N-S-equivalences is given by exterior maps which induce isomorphisms on the k-th N-exterior homotopy groups π N k for k ∈ S, where S is a set of non negative integers. The category(More)
aBSTRacT Diverse studies demonstrate that the future baby reacts to the sounds and the light in uterus four months before being born, that is to say, he is able to recognize stimulus which was exposed habitually, like the beats of the mothers heart and the voice of the same one when talk him before being born, likewise the music he used to heard during(More)
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