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We present methods for the analysis of a K-variate binary measure for two independent groups where some observations may be incomplete, as in the case of K repeated measures in a comparative trial. For the K 2 X 2 tables, let theta = (theta 1,..., theta K) be a vector of association parameters where theta k is a measure of association that is a continuous(More)
In this article we review the important statistical properties of the urn randomization (design) for assigning patients to treatment groups in a clinical trial. The urn design is the most widely studied member of the family of adaptive biased-coin designs. Such designs are a compromise between designs that yield perfect balance in treatment assignments and(More)
In a long term clinical trial to evaluate a new treatment, quite often each study subject may experience a number of 'failures' that correspond to repeated occurrences of the same type of event or events of entirely different natures during his/her follow-up period. To obtain efficient inference procedures for the therapeutic effect over time, it is(More)
The statistical properties of simple (complete) randomization, permuted-block (or simply blocked) randomization, and the urn adaptive biased-coin randomization are summarized. These procedures are contrasted to covariate adaptive procedures such as minimization and to response adaptive procedures such as the play-the-winner rule. General recommendations are(More)
Suppose that subjects are observed repeatedly over a common set of time points with possibly time-dependent covariates and possibly missing observations. At each time point we model the marginal distribution of the response variable and the effect of the covariates on that distribution using a class of quasi-likelihood models studied in McCullagh and(More)
In clinical trials repeated measurements of a response variable are usually taken at prespecified time-points to compare the treatment effects. However, the comparison of treatment effects is often complicated by missing data caused by the withdrawal of some patients before the end of the study (that is, drop-outs). When the drop-out process depends on the(More)
In comparing the effectiveness of two treatments, suppose that nondecreasing repeated measurements of the same characteristic are scheduled to be taken over a common set of time points for each study subject. A class of univariate one-sided global asymptotically distribution-free tests is proposed to test the equality of the two treatments. The test(More)
MOTIVATION Analysis of high-throughput proteomic/genomic data, in particular, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) data and microarray data, has led to a multitude of techniques aimed at identifying potential biomarkers. Most of the statistical techniques for comparing two groups are based on(More)