L J Rosenberg-Schaffer

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This two-part investigation explored the parameters and mechanisms of: (1) injury to spinal cord (SC) neurons by nonfreezing low temperatures, and (2) hypothermic protection of SC neurons subjected to a defined, physical injury (dendrite transection). Conclusions from the studies of hypothermic injury were: (1) morphologic and ultrastructural signs of(More)
The aim of this study was to test the hypothesis that ATP elevates cytosolic free Ca2+ levels ([Ca2+]i) in myenteric neurons expressing the Ca2+ binding protein, calbindin-D28. A laser microbeam marked the location of cultured neurons on coverslips and provided unequivocal relocation of ATP-responsive neurons after immunocytochemistry. All myenteric(More)
Cultured spinal neurons were subjected to dendrite amputation 100 microns from the perikaryon and treated with methylprednisolone (MP). Survival was significantly increased by 30 micrograms/ml MP but not by 10, 20 or 60 micrograms/ml. Survival was reduced by 100 micrograms/ml MP. These results suggest: (1) MP protects neurons subjected to physical trauma,(More)
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