L. J. Dijkstra

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Structural variation (SV) represents a major source of differences between individual human genomes and has been linked to disease phenotypes. However, the majority of studies provide neither a global view of the full spectrum of these variants nor integrate them into reference panels of genetic variation. Here, we analyse whole genome sequencing data of(More)
The criminal nature of narcotics complicates the direct assessment of a drug community, while having a good understanding of the type of people drawn or currently using drugs is vital for finding effective intervening strategies. Especially for the Russian Federation this is of immediate concern given the dramatic increase it has seen in drug abuse since(More)
Taking precautions before or during the start of a virus outbreak can heavily reduce the number of infected. The question which individuals should be immunized in order to mitigate the impact of the virus on the rest of population has received quite some attention in the literature. The dynamics of the of a virus spread through a population is often(More)
Structural variation (SV) represents a major source of differences between individual human genomes and has been linked to disease phenotypes. However, the majority of studies provide neither a global view of the full spectrum of these variants nor integrate them into reference panels of genetic variation. Here, we analyse whole genome sequencing data of(More)
Many disciplines, from human genetics and oncology to plant and animal breeding, microbiology and virology, commonly face the challenge of analyzing rapidly increasing numbers of genomes. In case of Homo sapiens, the number of sequenced genomes will approach hundreds of thousands in the next few years. Simply scaling up established bioinformatics pipelines(More)
Cancer is a genetic disorder in the first place. Therefore, next-generation sequencing (NGS) based discovery of somatically acquired genetic variants has gained widespread attention. Computational prediction of somatic variants, however, is affected by a variety of confounding factors. In addition to the uncertainties that one commonly encounters also in(More)
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