L. Iamele

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Little is known about the large ectodomain of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor (HGF/SF). Here, we establish by deletion mutagenesis that the HGF/SF and heparin-binding sites of MET are contained within a large N-terminal domain spanning the alpha-chain (amino acids 25-307) and the first 212(More)
The problem of data broadcasting over multiple channels consists in partitioning data among channels, depending on data popularities, and then cyclically transmitting them over each channel so that the average waiting time of the clients is minimized. Such a problem is known to be polynomially time solvable for uniform length data items, while it is(More)
The c-MET receptor has a function in many human cancers and is a proven therapeutic target. Generating antagonistic or therapeutic monoclonal antibodies (mAbs) targeting c-MET has been difficult because bivalent, intact anti-Met antibodies frequently display agonistic activity, necessitating the use of monovalent antibody fragments for therapy. By using a(More)
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