L H Ostrach

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The postnatal development of the ipsilateral retinocollicular projection in the rabbit and the effects of unilateral enucleation (performed on the day of birth, day 0) on that development were studied by using the anterograde axonal transport of tritiated proline injected intraocularly. Material from 1-, 6-, and 10-day-old (i.e., at days 1, 6, and 10) and(More)
Studies have shown that normal development of receptive field properties in striate cortex and lateral geniculate nucleus (LGN) of the rabbit is severely altered in the presence of penicillin-induced disruption of cortical neuronal activity. We wished to replicate these studies using a different convulsant drug in order to rule out possible effects due to(More)
We examined the effects of early epileptiform activity on development of visuocortical receptive fields in the rabbit. Aqueous penicillin was injected twice a day into a cannula implanted over the monocular area of one visual cortex. Drug administration was begun on postnatal day 8-9 and continued until postnatal day 24-30. Concomitant with the penicillin(More)
The effects of electrical stimulation of the visual cortex on superior colliculus neurons were investigated in adult Dutch-belted rabbits. Single units were recorded in the superior colliculus and classified as to receptive field type. Stimulation of the ipsilateral visual cortex activated 29% of the recorded superior colliculus units. No units were driven(More)
Previous studies have shown that unilateral enucleation of rabbit pups produces an aberrant uncrossed retinotectal projection. These fibers failed to drive collicular units when stimulated with either light or electric shock. The present study attempts to assess the possibility that enucleation at earlier stages of development would lead to a greater degree(More)
Chick embryos and young hatchling chicks have undergone unilateral retinal ablation and the brains were subsequently prepared for modified Fink-Heimer staining to detect degenerating axoplasm. Additional animals have been injected with tritiated proline or combinations of tritiated proline and tritiated fucose. In examining the patterns of degeneration and(More)
A comparison was made between penicillin- and bicuculline-induced epileptiform activity. Aqueous solutions of either penicillin or bicuculline were applied to striate cortex of rabbit pups, and the electroencephalogram was monitored. Applications were made twice daily for 14 consecutive days beginning on postnatal day 8-9. During this time period,(More)
Three groups of rabbits were reared with monocular eyelid suture. Percentages of cells with various receptive field types were determined by recording in the deprived visual cortex of animals 30-35 days, 46-55 days, and 20-36 months old. These results, together with previously published data from two other groups of monocularly deprived rabbits, are(More)
To further study the existence of a critical trophic period in the development of the chick optic tectum, during which the presence of retinal synapses is essential to the continued growth of tectal neurons, we have unilaterally enucleated embryos between stages 14--20 and allowed survival until stages 35--43. If the critical trophic period is between(More)
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