The assessment of tissue perfusion by dynamic contrast-enhanced (DCE) imaging involves a deconvolution process. For analysis of DCE imaging data, we implemented a regression approach to select appropriate regularization parameters for deconvolution using the standard and generalized singular value decomposition methods. Monte Carlo simulation experiments… (More)
PURPOSE Hemorrhagic transformation (HT) is a common consequence of infarction independent of thrombolytic therapy. Our purpose was to examine if permeability imaging in admission perfusion CT data of patients with acute stroke might indicate a subsequent HT by imaging the disrupted permeability barriers between blood and brain. MATERIALS AND METHODS A… (More)
A sequence of images acquired by a moving sensor contains information about the three-dimensional motion of the sensor and the shape of the imaged scene. Interesting research during the past few years has attempted to characterize the errors that arise in computing 3D motion (egomotion estimation) as well as the errors that result in the estimation of the… (More)
We present two regression models for the automatic estimation of bolus arrival times (BATs) in dynamic contrast MRI datasets. Results of Monte Carlo simulation experiments show that the means and standard deviations of the estimated BATs are within the sampling interval even in the presence of significant noise.
Quantitative estimates of physiological parameters associated with cerebral blood flow can be derived from the analysis of dynamic contrast-enhanced (DCE) images, using an appropriate model of the underlying tissue impulse residue function. The theoretical formulation of a distributed parameter model of tissue microcirculation, which accounts for the… (More)
We are surrounded by surfaces that we perceive by visual means. Understanding the basic principles behind this perceptual process is a central theme in visual psychology, psychophysics and computational vision. Metric descriptions of physical space encoding distances between features in the environment have been used throughout the ages for various… (More)
Dynamic contrast-enhanced (DCE) imaging using MRI or CT is emerging as a promising tool for diagnostic imaging of cerebral disorders and the monitoring of tumor response to treatment. In this study, we present a robust and efficient deconvolution method based on a linearized model of the impulse residue function, which allows for the mapping of functional… (More)
The study of visual navigation problems requires the integration of visual processes with motor control. Most essential in approaching this integration is the study of appropriate spatiotemporal representations that the system computes from the imagery and that serve as interfaces to all motor activities. Since representations resulting from exact metric… (More)