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The effects of lormetazepam (0.03 mg/kg IV) a benzodiazepine (BZ) derivative in combination with ZK 93 426 (0.04 mg/kg IV) a β-carboline, benzodiazepine receptor antagonist were evaluated in humans. Independently, the effects of ZK 93 426 on its own were investigated. A psychometric test battery to evaluate sedation (visual analog scales (VAS), anxiolysis(More)
Oxford Medical has introduced an automatic sleep stager based on the stage-scoring criteria by Rechtschaffen and Kales. With our study we intended to examine whether the results of the stager (version 3.0) match those of the visual evaluation by two independent raters. We also wanted to test the reliability of this automatic sleep stage-scoring system. Ten(More)
The Oxford Medilog 9000 System with Sleep Stager, a device for the mobile recording of sleep EEGs and automatic analyses of sleep, was tested with regard to its functional capacity, possible applications and reliability. Four all-night sleep records were evaluated visually and compared with the automatic analysis. Tendentially uniform differences were(More)
First results from studies in healthy subjects with the beta-carbolines ZK 91 296, ZK 95 962 and ZK 93 426 are reviewed. ZK 91 296 and ZK 95 962, characterized as partial benzodiazepine agonists in preclinical research, were unable to induce some typical benzodiazepine effects like sedation when administered intravenously in high doses. ZK 95 962, reported(More)
Many studies have already demonstrated that the restenosis rate after carotid endarterectomy is greater as expected since ultrasound examination has become a routine procedure after endarterectomy. The purpose of our randomized study is to compare the rates of restenosis with two methods of carotid endarterectomy--direct suturing and autologous vein(More)
Two clinical-pharmacological investigations were performed to give a retrospective and explorative record, based on electroencephalographic parameters, of spindle density and REM distribution in the first and second halves of the night under a short-acting (triazolam) and medium-acting (lormetazepam) benzodiazepine. A further aim was to determine whether a(More)
The rules by Rechtschaffen and Kales present numerous problems; they sometimes even contradict physiological facts. This is due on the one hand to the manual being limited to central leads only, and on the other hand to rules which are partly too narrow, partly too broad and partly too complex. Furthermore, there are situations and physiological facts for(More)
A short sleep portion in an otherwise routinely performed EEG evaluation is often highly informative. This is particularly true for epileptological conditions. Several paroxysmal discharges are demonstrable solely in sleep and/or drowsiness; these potentials remain undetected in a waking tracing. Hence the inclusion of a sleep portion may be crucial in the(More)
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