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In a previous paper we studied the spread of excitation in a simplified model of the left ventricle, affected by fiber structure and obliqueness, curvature of the wall and Purkinje network. In the present paper we investigate the extracellular potential distribution u in the same ventricular model. Given the transmembrane potential v, associated with the(More)
The potential distribution in a homogeneous, cylindrical volume conductor surrounding an isolated paced dog heart was first measured and then calculated by using a mathematical model that stimulates an anisotropic excitation wavefront spreading through the heart muscle. The study was performed with a view to establish to what extent the anisotropy of(More)
In this work we investigate, by means of numerical simulations, the performance of two mathematical models describing the spread of excitation in a three dimensional block representing anisotropic cardiac tissue. The first model is characterized by a reaction-diffusion system in the transmembrane and extracellular potentials v and u. The second model is(More)
We study the properties of the potential field generated by an oblique dipole layer. This field arises, for instance, in describing the potential elicited by a depolarization wavefront spreading in the myocardium when a dependence of the potential on the cardiac fiber orientation is introduced. The representation of cardiac bioelectric sources by means of(More)
INTRODUCTION We present simulations of extracellular potential patterns elicited by delivering ectopic stimuli to a parallelepipedal slab of ventricular tissue represented as an anisotropic bidomain incorporating epi-endocardial fiber rotation. METHODS AND RESULTS Simulations were based on an eikonal model that determines wavefront shapes throughout the(More)
In this paper we present a macroscopic model of the excitation process in the myocardium. The composite and anisotropic structure of the cardiac tissue is represented by a bidomain, i.e. a set of two coupled anisotropic media. The model is characterized by a non linear system of two partial differential equations of parabolic and elliptic type. A singular(More)
INTRODUCTION The purpose of this study was to present simulations of excitation wavefronts spreading through a parallelepipedal slab of ventricular tissue measuring 6.5 x 6.5 x 1.0 cm. METHODS AND RESULTS The slab incorporates the anisotropic properties of the myocardium including the transmural counterclockwise fiber rotation from epicardium to(More)
In our macroscopic model the heart tissue is represented as a bidomain coupling the intra- and extracellular media. Owing to the fiber structure of the myocardium, these media are anisotropic, and their conductivity tensors have a principal axis parallel to the local fiber direction. A reaction-diffusion system is derived that governs the distribution and(More)
We investigate a three-dimensional macroscopic model of wave-front propagation related to the excitation process in the left ventricular wall represented by an anisotropic bidomain. The whole left ventricle is modeled, whereas, in a previous paper, only a flat slab of myocardial tissue was considered. The direction of cardiac fibers, which affects the(More)
The origin of the multiple, complex morphologies observed in unipolar epicardial electrograms, and their relationships with myocardial architecture, have not been fully elucidated. To clarify this problem we simulated electrograms (EGs) with a model representing the heart as an anisotropic bidomain with unequal anisotropy ratio, ellipsoidal ventricular(More)