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The urinary excretion of purine derivatives (PD) was measured in six buffaloes (Bubalis bubalis) during fasting and in fourteen buffaloes given four restricted levels of roughage (2.5-4.8 kg DM/d). Only allantoin and uric acid, not xanthine and hypoxanthine, were present in the urine, the pattern of excretion being similar to that in cattle. The fasting PD(More)
Neuroblastoma (NB) is the most common extracranial solid tumor in children. NB tumors and derived cell lines are phenotypically heterogeneous. Cell lines are classified by phenotype, each having distinct differentiation and tumorigenic properties. The neuroblastic phenotype is tumorigenic, has neuronal features and includes stem cells (I-cells) and neuronal(More)
This paper presents the results of the EFOOL project. EFOOL (Evaluation of Functional and Object-Oriented Languages) is a quantitative evaluation of the functional and object-oriented paradigms. The aim of the project is to investigate whether or not the quality of code produced using a functional language is significantly different from that produced using(More)
The importance of replication of software engineering ezperi-mentation to validate ezperimental results, (considered normal practice in other scientific domains) has often been overlooked. This paper presents the results of an internal repli-cation of a case study which quantitatively investigates and compares the quality of code produced in a functional(More)
This paper describes an investigation into measuring the quality of functional programs. The work reported here is part of a larger, ongoing study into a q u a n titative analysis of the eeect of utilizing diierent programming paradigms on code quality. Prior to undertaking such a comparative analysis it is necessary to establish a baseline of quality(More)
Neuroblastoma is a childhood cancer originating from embryonic neural crest cells. Amplification of the proto‑oncogene N-myc, seen in ~30% of neuroblastoma tumors, is a marker for poor prognosis. Recently discovered small regulatory RNAs, microRNAs (miRNAs), are implicated in cancers, including neuroblastoma. miRNAs downregulate the expression of genes by(More)